• Main page
• About the journal
• Editorial board
• Subscription
• Information for contributors
• Editorial and Peer Review
• Issues archive
• Authors
• Articles
  • By alphabet
  • By category
• Blogs and comments

The journal is included into The list of leading scientific periodicals.

The journal is included into VINITI database and is registered in Electronic scientific library.

The journal is indexed by SCOPUS, Ulrich's International Periodicals Directory.

EBSCO

https://doi.org/10.14300/mnnc.2024.19066

Matrix metalloproteinases as a marker of cirrhotic portal vein thrombosis

[Internal diseases]
Temirlan Ruslanovich Dudov; Lalita Sidykovna Baisaeva; Pavel Koroy; Alexandr Yagoda;

In 159 patients with liver cirrhosis the relationship between matrix metalloproteinase-1 (MMP-1), MMP-9, tissue inhibitors metalloproteinases-1 (TIMP-1) with portal vein thrombosis (PVT) was studied. The prevalence of PVT among hospitalized patients with liver cirrhosis was 6.9 %. The patients with liver cirrhosis and PVT had a lower levels of MMP-9 in blood (p<0.05) and higher values of TIMP-1/MMP-9 ratio (p<0.05). An increased chance of PVT in liver cirrhosis was associated with MMP-9 less than 103 ng/ml (odds ratio (OR) 5.07; 95 % confidence interval (CI) 1.29–19.95), p<0.05) and TIMP-1/MMP-9 ratio above 7.4 (OR 5.44; 95 % CI 1.51–19.67), p<0.05). The diagnostic accuracy of above-mentioned indicators of MMP-9 and of TIMP-1/MMP-9 ratio in PVT prediction was 66.0 % and 74.8 %, respectively.

Download

References:
1. Boccatonda A., Gentilini S., Zanata E., Simion C., Serra C. [et al.]. Portal vein thrombosis: state-of-the-art review. J. Clin. Med. 2024;13:1517. https://doi.org/10.3390/jcm13051517
2. Yagoda A. V., Koroy P. V., Baisaeva L. S., Dudov T. R. Portal vein thrombosis in liver cirrhosis. Part 1: epidemiology, pathogenesis, clinic, diagnosis, impact on prognosis. Arhiv vnutrennej mediciny. – The Russian Archives of Internal Medicine. 2024;14(3):165-172. (In Russ.). https://doi.org/10.20514/2226-6704-2024-14-3-165-172
3. Koroy P. V., Dudov T. R., Yagoda A. V., Sarithala V. J. Matrix metalloproteinases: the role in evolution of liver diseases (literature review). Medical News of North Caucasus. 2023;18(2):219-225. https://doi.org/10.14300/mnnc.2023.18052
4. Yu Q., Li K., Xu Y., Chu H., Zhang H. [et al.]. The expression of matrix metalloproteinases and their tissue inhibitors in the vein wall following superficial venous thrombosis. Phlebology. 2022;37(1):63-71. https://doi.org/10.1177/02683555211043332
5. Zhang T., Li Q., Wang L., Li G. Expression variations and clinical significance of MMP-1, MMP-2 and inflammatory factors in serum of patients with deep venous thrombosis of lower extremity. Exp. Ther. Med. 2019;17(1):181-186. https://doi.org/10.3892/etm.2018.6922
6. Abdel-Atti E. A., Bedair H. M., Elgendy M. A. A., Allah A. N. A. A. G. Study the relation of portal vein thrombosis and a disintegrin and metalloproteinase with thrombospondin-13 level in patients with liver cirrhosis. J. Pharmac. Neg. Res. 2022;13(9):7517-7525. https://doi.org/10.47750/pnr.2022.13.S09.882
7. Suzuki J., Namisaki T., Takya H., Kaji K., Nishimura N. [et al.]. ADAMTS-13: a prognostic biomarker for portal vein thrombosis in Japanese patients with liver cirrhosis. Int. J. Mol. Sci. 2024;25:2678. https://doi.org/10.3390/ijms25052678
8. De Franciscis S., Gallelli L., Amato B., Butrico L., Rossi A. [et al.]. Plasma MMP and TIMP evaluation in patients with deep venous thrombosis: could they have a predictive role in the development of post-thrombotic syndrome? Int. Wound J. 2016;13:1237-1245. https://doi.org/10.1111/iwj.12489

Keywords: liver cirrhosis, portal vein thrombosis, matrix metalloproteinases