logo
Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
rus
русский
eng
english

Site search



Correspondence address
310 Mira Street, Stavropol, Russia, 355017

Tel
+7 865 2352511, +7 865 2353229.

E-mail
medvestnik@stgmu.ru

Study of cyp2c9 gene polymorphism in ethnic groups of the population of stavropol region

[Clinical Pharmacology]
Vladimir Baturin; Anna Tsarukyan; Elena Kolodijchuk;

Study of CYP2C9*2 and CYP2C9*3 prevalence in ethnic groups of Stavropol territory (Slavs, Armenians, Karachai and Turkmen) was carried out. The genotypes analysis allowed to reveal significant total share of «slow» metabolizers among representatives of studied ethnic groups. This amount varies from 28 % in Karachai and 31,5 % in Turkmen to 36 % in Slavs and56 % in Armenian population. The high occurrence of allelic CYP2C9*3 polymorphism can serve as the predicting marker of the increased risk of bleedings in Armenians treated by warfarin. Perhaps, Armenians are more sensitive to drugs – substrates for CYP2C9 (oral anticoagulants, oral hypoglycemic agents, NSAID).

Download

References:
1. Kukes V. G.,Grachev S. V., Sychev D. A., Ramenskaya G. V. Metabolizm lekarstvennykh sredstv: nauchnye osnovy personalizirovannoy meditsiny. M.: GEOTAR-Media; 2008. 304 p.
2. Romodanovsky D. P., Khapayev B. A., Ignatyev I. V., Kukes V. G., Karkishchenko V. N. Biomeditsina. – Biomedicine. 2010;2:33-37.
3. Seredenin S. B. Lektsii po farmakogenetike. M.: MIA; 2004. 303 p.
4. Sychev D. A. Stasyak Ye.V., Ignatyev I.V., Bulytova Yu.M., Ramenskaya G.V., Kukes V.G. Klinicheskaya farmakologiya i terapiya. – Сlinical pharmacology and therapeutics. 2005;14(4):60-63.
5. Sychev D. A., Ramenskaya G. V., Ignatyev I. V., Kukes V. G. Klinicheskaya farmakogenetika: uchebnoye posobiye. M.: GEOTAR-Media; 2007. 248 p.
6. Khokhlov A.L., Sirotkina A.M., Voronina Ye.A., Lileyeva Ye. G., Rybachkova Yu. V., Mogutova I.S., Melnikova Yu. Ye., Mogutov M. S., Dryazhenkova I. V., Limonova O. A. Vestnik Severo-Zapadnogo gosudarstvennogo meditsinskogo universiteta imeni I. I. Mechnikova. – North-West State Medical University named after I.I. Mechnikov. 2012;4(2):80-86.
7. Tsarukyan, A. A, Baturin V. A. Uchenye zapiski Orlovskogo gosudarstvennogo universiteta. – Scientific Notes Of Orel State University. 2013;6(56):279-283.
8. Becquemont L., Alfirevic A., Amstutz U., Brauch H., Jacqz-Aigrain E., Laurent-Puig P., Molina M. A., Niemi M., Schwab M., Somogyi A. A., Thervet E., Maitland – van der ZeeA. H., van Kuilenburg A.B., van Schaik R.H., Verstuyft C., Wadelius M., Daly A. K. Pharmacogenomics. 2010;12(1):113-124.
9. Blaisdell J., Jorge-Nebert L.F., Coulter S., Ferguson S.S., LeeS. J., Chanas B., Xi T., Mohrenweiser H., Ghanayem B., Goldstein J.A. Pharmacogenetics. 2004;14(8):527-537.
10. Gaikovitch E. A., Cascorbi I., Mrozikiewicz P. M., Brockmoller J., Frotschl R., Kopke K., Gerloff T., Chernov J. N., Roots I. European Journal Of Clinical Pharmacology. 2003;59(4):303-312.
11. Kidd R. S., Curry T. V., Gallagher S., Edeki T., Blaisdell J., Goldstein J. A. Pharmacogenetics. 2001;11(9):803-808.
12. Kirchheiner J., Brockmoller J. Clinical Pharmacology & Therapy. 2005;77(1):1-16.
13. Loebstein R., Dvoskin I., Halkin H., Vecsler M., Lubetsky A., Rechavi G., Amariglio N., CohenY., Ken–Dror G., Almong S., Gak E. Blood. 2007;109(6):2477-2480.
14. Martin J. H., Begg E. J., Kennedy M. A., Roberts R., Barclay M. L. British journal of clinical pharmacology. 2001;51(6):627-630.
15. Momary K. M., Shapiro N. L., Viana M. A., Nutescu E. A., Helgason S.M., Cavallari L.H. Pharmacogenomics. 2007;8(11):1535-1544.
16. Rosemary J., Adithan C. Current Clinical Pharmacology. 2007;2:93 -109.
17. Rost S., Fregin A., Flunerberg M., Bevans S. G., Muller C. R., Oldenburg J. Thrombosis and Haemostasis. 2005;94(4):780-786.
18. Sconce E. A., Daly A. K., Khan T. I., Wynne H. A., Kamali F. Pharmacogenetics and genomics. 2006;16(8):609-611.
19. Solus J. F., Arietta B. J., Harris J. R., Sexton D. P., Steward J. Q., McMunn C., Ihrie P., Mehall J. M., Edwards T. L., Dawson E. P. Pharmacogenomics. 2004;5(7):895-931.
20. Zhu Y., Shennan M., Reynolds K. K., Johnson N. A., Herrnberger M. R., Valdes R., Linder M. W. Clinical Chemistry. 2007;53(7):1199-1205.

Keywords: biotransformation, cytochrome P-450, CYP2C9, ethnic features, gene polymorphism


Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy