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Medical news
of the North Caucasus
Scientific journal
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Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
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Biocompatibility of cell cultures with new titanium alloy samples used for dental implantology

[Abstracts]
Nikolay Didenko; Dmitry Bobryshev; Alexander Dolgalev; Sofya Romanovna Adeshelidze; David Zurabovich Choniashvili; Himalay Kazbekovich Gezuev; Rustam Millatullakhovich Omarov; Bela Khamzetovna Tlyabicheva;

The study contains the outcomes of evaluating the proliferative activity of primary cultures of mesenchymal stem cells (MSCs) of mouse adipose tissue in case of using BT 1.0 and BT 6 titanium alloy experimental samples either with no coating or with different degrees, types of treatment and coatings. The MSCs cultured on samples of BT 6 titanium alloy treated with an electron beam coated with ALD and TiO2 (thickness – 25 nm) and with an ion plasma coating of TiO2 (thickness – 2 microns) featured a significantly higher level of proliferative activity. Thus, the data obtained in the work showed further prospects for studying their osseointegrative properties under experimental conditions employing in vivo models.

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References:
1. Virnik S., Cueni L., Kloss-Brandstätter A. Is one-stage lateral sinus lift and implantation safe in severely atrophic maxillae? Results of a comparative pilot study. Int. J. Implant. Dent. 2023;9(1):6. https://doi.org/10.1186/s40729-023-00471-5
2. Inchingolo A. M., Malcangi G., Ferrante L., Del Vecchio G., Viapiano F. [et al.]. Surface Coatings of Dental Implants: A Review. J. Funct. Biomater. 2023;14(5):287. https://doi.org/10.3390/jfb14050287
3. Rausch M. A., Shokoohi-Tabrizi H., Wehner C., Pippenger B. E., Wagner R. S. [et al.]. Impact of Implant Surface Material and Microscale Roughness on the Initial Attachment and Proliferation of Primary Human Gingival Fibroblasts. Biology. 2021;10:356. https://doi.org/10.3390/biology10050356
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5. Zaika A. I., Savchik A. B., Birka I. I., Voroniak M. I., Siry O. M. Effect titanium on the osteogenic and proliferative potentials cells in vitro. Stomatologiia. – Dentistry. 1989;68(3):42-44. (In Russ.).

Keywords: dental implantation, mesenchymal stem cells, osseointegration, titanium, implant coating


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Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy