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https://doi.org/10.14300/mnnc.2024.19053

Morphological changes in the primary somatosensory cortex of the rat brain in experimental type 1 diabetes mellitus and pharmacological correction taking into account the expression of BDNF

[Experimental medicine]
Alexey Vladimirovich Smirnov; Ivan Nikolaevich Tyurenkov; Aislu Ilnurovna Bisinbekova; Dmitry Aleksandrovich Bakulin; Julia Ivanovna Velikorodnaya;

This study looked at changes in the morphofunctional alterations and the characteristics of BDNF expression in the primary somatosensory cortex under conditions of experimental Type 1 diabetes (T1D) and pharmacological intervention.

The research was conducted on 18-month-old laboratory rats (N=50) with prolonged (6-month) T1D. When studying the primary somatosensory cortex of the brain of mature rats, a relationship was found between the expression of cerebral neurotrophic factor (BDNF) and the degree of neurodegenerative changes in diabetic encephalopathy. The study revealed a decrease in BDNF expression mainly in damaged neurons. Moreover, 4-week treatment with GABA derivatives contributed to an increase in BDNF expression in the external pyramidal and internal pyramidal layers of the primary somatosensory cortex of the brain.

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Keywords: brain, diabetes mellitus, diabetic encephalopathy, neurodegeneration, BDNF, GABA