• Main page
• About the journal
• Editorial board
• Subscription
• Information for contributors
• Editorial and Peer Review
• Issues archive
• Authors
• Articles
  • By alphabet
  • By category
• Blogs and comments

The journal is included into The list of leading scientific periodicals.

The journal is included into VINITI database and is registered in Electronic scientific library.

The journal is indexed by SCOPUS, Ulrich's International Periodicals Directory.

EBSCO

https://doi.org/10.14300/mnnc.2024.19012

Characteristics of the histological structure of tooth tissues in experimental hypothyroidism and administration of iodsteviolglycoside

[Experimental medicine]
Timur Irekovich Ganeev; Felix Khusainovich Kamilov; Valery Nikolaevich Kozlov; Ekaterina Rafaelevna Farshatova; Sergey Sirak; Alla Sirak; Timur Nailevich Shaimardanov;

Morphological changes in tooth and periodontal tissues in experimental animals and the possibility of correction using iodine saccharide based on steviolglycoside rebaudioside A were studied using a hypothyroidism model (thiamazole for 21 days, 25 mg/kg weight). It was found that experimental thyroid dysfunction, formed in rats for three weeks, leads to longterm uncompensated changes in the structural components of the tooth and surrounding tissues, which are manifested by microcirculation disorders and signs of inflammatory phenomena, resorption of the alveolar bone, violation of the processes of enamel and dentin formation. At the background of the formed hypothyroidism model, the 30-day use of iodosteviolglycoside rebaudioside A, as well as iodomarin, accelerated the normalization of pathological changes in rat tooth and periodontal tissues.

Download

References:
1. Rahangdale S. I., Galgali S. R. Periodontal status of hypothyroid patients on thyroxine replacement therapy: A comparative cross-sectional study. J. Indian Soc. Periodontol. 2018;22(6):535-540. https://doi.org/10.4103/jisp.jisp_316_18
2. Vucic S., Korevaar T. I. M., Dhamo B., Jaddoe V. W. V., Peeters R. P. [et al.]. Thyroid Function during Early Life and Dental Development. J. Dent. Res. 2017;96(9):1020- 1026. https://doi.org/10.1177/0022034517708551
3. Botasheva V. S., Kubanova A. B., Melchenko E. A. Morphofunctional state of hard dental tissues according to scanning probe microscopy in experimental hypothyroidism. Volgogradskiy nauchno-medicinskiy zhurnal. – Volgograd scientific and medical journal. 2020;(3):49-53. (In Russ.).
4. Averyanov S. V., Kamilov F. Kh., Yunusov R. R. The relationship between the functional state of the thyroid gland, the mineral density of the skeletal bone tissue and indicators of the oral health status in patients. Dental Forum. 2020;(1):2-8. (In Russ.).
5. Gecgelen Cesur M., Cesur G., Ogrenim M., Alkan A. Do prenatal and postnatal hypothyroidism affect the craniofacial structure?: An experimental study. Angle Orthod. 2016;86(5):854-861. https://doi.org/10.2319/080315-521.1
6. Troshina E. A., Platonova N. M., Panfilova E. A., Panfilov K. O. Analytical review of the results of monitoring the main epidemiological characteristics of iodine deficiency diseases of the population of the Russian Federation for the period 2009–2015. Problemi endokrinologii. – Problems of Endocrinology. 2018;64(1):21-37. (In Russ.).
7. Choudry H., Nasrullah M. Iodine consumption and cognitive performance: Confirmation of adequate consumption. Food Sci. Nutr. 2018;6(6):1341-1351. https://doi.org/10.1002/fsn3.694 8. Guideline: Fortification of Food-Grade salt with iodine for the Prevention and Control of Iodine Deficiency Disorders. Geneva: World Health Organization, 2014.
9. Farebrother J., Zimmermann M. B., Anderson M. Excess iodine intike:sources, assessment, and effects on thyroid function. Ann. N.Y. Acad. Sci. 2019;1446(1):44-65. https://doi.org/10.1111/nyas.14041
10. Hennessy A. N., Chaoimh C., McCarthy E. K., Kingston C., Irvina A. D. [et al.]. Variation in iodine food composition data has a major impact on estimates of iodine intake in young children. Eur. J. Clin. Nutr. 2018;72(3):410-419. https://doi.org/1038/s41430-017-0030-9
11. Bali S., Tomar A., Nayak P. K., Bekwal R. No longer Prevalent and Urinary Iodine Expression Is above Normal among School Going Children in Jabalpur, India: Is This Major Health Problem Already Solved? J. Trop. Pediatr. 2019;65(5):457-462. https://doi.org/10.1093/tropcj/fmy076 12. Wassie M. M., Midelleton P., Zhou P. Agreement between markers of population iodine status in classifying iodine status of populations: a systematic review. Am. J. Clin. Nutr. 2019;110(4):949-958. https://doi.org/10.1093/ajcn/nqz118
13. Kamilov F. Kh., Ganeev T. I., Kozlov V. N., Kuznetsova E. V., Maksyutov R. R. Choice of method of application and dose of thiamazole for modeling hypothyroidism. Biomedicina. – Biomedicine. 2018;(1):59- 70. (In Russ.).
14. Kamilov F. H., Konkina I. G., Murinov Yu. I., Ivanov S. P., Ivanova G. V. [et al.]. Method of obtaining an iodinecontaining biologically active food additive. Patent RU № 1717045, dated 17.03.2020. (In Russ.).
15. Aldulaijan H. A., Cohen R. E., Stellrecht E. M., Levine M. J., Yerke L. M. Relationship between hypothyroidism and periodontitis: A scoping review. Clin. Exp. Dent. Res. 2020;6(1):147-157. https://doi.org/10.1002/cre2.247
16. Botasheva V. S., Kubanova A. B. Assessment of the nature and dynamics of structural changes in hard tooth tissues in hypothyroidism (experimental study). Medicinskij alfavit. – Medical Alphabet. 2017;3(24):59-62. (In Russ.).
17. Zeng Y., Deng J. J., Jiang Q. L., Wang C. L., Zhang L. [et al.]. Thyrotropin inhibits osteogenic differentiation of human periodontal ligament stem cells. J. Periodontal Res. 2023;58(3):668-678. https://doi.org/10.1111/jre.13109

Keywords: experimental hypothyroidism, teeth, periodontal tissues, iodosteviolglycoside rebaudioside A, histological structure