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of the North Caucasus
Scientific journal
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Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
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Influence of the mesenchymal stem cells exosomes and defensin on the biocompatibility of material for replacement of osteocartilage defects

[Abstracts]
Nikolay Didenko; Evgeny Mikhailovich Boyko; Artur Akhmatovich Chagarov; Albert Bolatchiev; Dmitry Bobryshev; Alexander Dolgalev;

The proliferative activity of primary cultures of rabbit adipose tissue derivate mesenchymal stromal cells was assessed using experimental samples based on collagen from the submucosa of the pig small intestine, containing MSC exosomes and DEFb103A. The materials are not cytotoxic and do not interfere with the proliferative activity of cells. The results obtained are allow providing the in vivo studies of the biocompatibility of materials.

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References:
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4. Baust J. M., Buehring G. C., Campbell L., Elmore E., Harbell J. W. [et al.]. Best practices in cell culture: an overview. In Vitro Cell Dev. Biol. Anim. 2017;53(8):669-672. https://doi.org/10.1007/s11626-017-0177-7
5. Dolgalev A. A., Boyko E. M., Bobryshev D. V., Didenko N. N., Gumskova Yu. A. [et al.]. Issledovaniye tsitotoksichnosti kollagen-soderzhashchikh geley na eksperimental’nykh obraztsakh biomaterialov. Meditsinskii vestnik Severnogo Kavkaza. – Medical News of North Caucasus. 2022;17(1):74-75. (In Russ.). https://doi.org/10.14300/mnnc.2022.17020

Keywords: collagen gel, extracellular matrix, implantation


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Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy