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https://doi.org/10.14300/mnnc.2023.18084

Dynamics of neopterin and C-reactive protein levels in the blood of children with COVID-19 coronavirus infection

[Pediatrics]
Marina Golubeva; Araratovna  Musaelyan Olga; Yuliya Vladimirovna  Borisova; Boris Sergeevich  Shaposhnikov; Zalina Vladimirovna  Bolloeva; Larisa Pogorelova;

Complex determination of neopterin (NP) and CRP concentrations in children with COVID-19 was performed on the 1–7 and 8–14 days from the onset of the disease. The analysis of one-stage determination of the studied parameters showed that the level of NP <35.7 nmol/l, combined with a low level of CRP <13.5 mg/l during the period of viral load is a predictor of a favorable course of the disease. On the contrary, the risk of unfavorable course of the disease is possible with CRP concentration ≥13.5 mg/L and NP ≥35.7 nmol/L during the period of increasing viral load. Further increase in the levels of CRP (≥31.5 mg/L) and NP (≥41.8 nmol/L) by the period of pathological immune response characterizes the picture of severe COVID-19 and predicts an unfavorable outcome. Correlation analysis revealed the presence of a reliable direct relationship between the studied indicators.

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Keywords: coronavirus infection COVID-19, neopterin, C-reactive protein