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EBSCO

https://doi.org/10.14300/mnnc.2023.18080

Rationale for the choice of a method for functional assessment of nerve regeneration when replacing defect with a biosynthetic analogue

[Reviews]
Vladimir Pokrovsky; Alexander Nikolaevich Ardelyan; Nanar Armoevna Harutyunyan; Bela Sultanmuratovna Tashu; Oleg Yaroslavovich Shcherbakov; Stanislav Sergeevich Pilipenko;

The existing methods of functional evaluation of nerve regeneration were analyzed in order to select a suitable method for replacing the defect with a biosynthetic analogue. The search of literary sources is carried out in the databases eLIBRARY and PubMed with a selection of foreign articles published over the past 10 years, whichinclude the designs of research and methods of functional evaluation of the nerve regeneration process along with classical morphological methods. Analysis of the presented works allowed making a choice in favor of a combination of minimally invasive and invasive methods. The minimally invasive approach is represented by the neuromyographic method of signal evaluation in the muscle in response to the percutaneous stimulation of the sciatic nerve projection point. As an invasive approach, it is planned to use signal recording directly in the nerve, i.e., the evaluation of a neurogram. The basis for the choice of neurography was the results of an experiment on the sciatic nerve of an anesthetized rat using the anode block as a model of nerve damage. Combining these methods can improve the functional evaluation of nerve regeneration when a defect is replaced by a biosynthetic analogue.

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Keywords: neurogram, graft, distal end, proximal end