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EBSCO

https://doi.org/10.14300/mnnc.2023.18071

Tear fluid cytokines as potential biomarkers for primary open-angle glaucoma

[Abstracts]
Lyudmila Barycheva; Daria Mikhailovna Kakulia; Milana Minasyan;

An increase in proinflammatory interleukins plays a critical role in glaucoma neurodegeneration. In a prospective «case-control» study, TNFα, IL1β, IL10 were determined in the lacrimal fluid of 56 patients (107 eyes) with primary open-angle glaucoma (POAG) and 30 patients (42 eyes) of the comparison group by enzyme-linked immunosorbent assay method. An increase in the content of TNFα – 94 was revealed [45; 165] pg/ml and IL1β – 4.30 [1.85; 6.70] pkg/l in tear fluid samples of patients with POAG. A decrease in the thickness of the retinal nerve fiber layer moderately correlated with an increase in the content of TNFα (r= 0.48, p=0.0001) and IL1β (r=–0.36, p=0.0001). An increase in the risk of developing glaucoma was found in patients with TNFα values exceeding 165 pg/ml (OR=7.09, CI=1.61–3.27), p=0.004.

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References:
1. Fernández-Vega Cueto A., Álvarez L., García M., ÁlvarezBarrios A., Artime E. [et al.]. Candidate Glaucoma Biomarkers: From Proteins to Metabolites, and the Pitfalls to Clinical Applications. Biology (Basel). 2021;10(8):763. https://doi.org/10.3390/biology10080763
2. Tezel G. Molecular regulation of neuroinflammation in glaucoma: Current knowledge and the ongoing search for new treatment targets. Prog. Retin. Eye Res. 2022;87:100998. https://doi.org/10.1016/j.preteyeres.2021.100998
3. Csősz É., Deák E., Tóth N., Traverso C. E., Csutak A. [et al.]. Comparative analysis of cytokine profiles of glaucomatous tears and aqueous humour reveals potential biomarkers for trabeculectomy complications. FEBS Open Bio. 2019;9(5):1020-1028. https://doi.org/10.1002/2211-5463.12637
4. Cherednichenko L. P., Barycheva L. Yu., Bernovskaya A. A. Significance of pro-inflammatory cytokines in the development of primary open-angle glaucoma. Meditsinskii vestnik Severnogo Kavkaza. – Medical News of North Caucasus. 2013;8(2):52-54. (In Russ.).
5. Auler N., Tonner H., Pfeiffer N., Grus F. H. Antibody and Protein Profiles in Glaucoma: Screening of Biomarkers and Identification of Signaling Pathways. Biology (Basel). 2021;10(12):1296. https://doi.org/10.3390/biology10121296

Keywords: primary open-angle glaucoma, lacrimal fluid, TNFα, IL1β, IL10