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The use of an epineurial prosthesis and direct electrical stimulation in the treatment of traumatic intra-trunk injuries of the median nerve

[Original research] [Neurology]
Anna Viktorovna Zorkova; Vera Naumovna Grigorieva; Sergei Karpov;

The efficiency of the therapeutic use of synthetic epineural coating in combination with electrical stimulation of the median nerve in its injuries without a complete anatomical break has been studied. The 43 patients with intra-trunk damage of the median nerve in the lower third of the forearm were examined. From them the 22 patients underwent external neurolysis of the median nerve, 21 patients underwent external nerve neurolysis with the additional use of a synthetic (made of hydrophobic acrylic) epineurium simulator in combination with its electrical stimulation. Surgical treatment using the artificial epineurium prosthesis and direct electrical nerve stimulation resulted in a statistically more significant restoration of hand muscle strength and restoration of arm function in the first six months after the intervention compared with isolated external neurolysis. The use of synthetic epineural coating in combination with neurolysis and electrical stimulation demonstrated an increase in the effectiveness of the treatment of patients with traumatic intra-trunk injuries of the median nerve.

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References:
1. El-Haj M., Ding W., Sharma K., Novak C., Mackinnon S. E., Patterson J. M. M. Median Nerve Compression in the Forearm: A Clinical Diagnosis. Hand (NY). 2021;16(5):586-591. https://doi.org/10.1177/1558944719874137
2. Soubeyrand M., Melhem R., Protais M., Artuso M., Crézé M. Anatomy of the median nerve and its clinical applications. Hand Surg. Rehabil. 2020;39(1):2-18. https://doi.org/10.1016/j.hansur.2019.10.197
3. Peperkamp K., Natroshvili T., Malyar M. A., Heine E. P., Walbeehm E. T. Anatomic Variations and Malformations as Rare Causes of Median Nerve Compression in Adults: A Narrative Review. Ann. Plast. Surg. 2022;1;88(2):237-243. https://doi.org/10.1097/sap.0000000000002813
4. Groen J. L., Pondaag W., Malessy M. J. A. Surgical treatment of nerve lesions. Ned. Tijdschr. Geneeskd. 2020;8;164:D4581.
5. Gordon T. Peripheral Nerve Regeneration and Muscle Reinnervation. Int. J. Mol. Sci. 2020;17;21(22):8652. https://doi.org/10.3390/ijms21228652
6. Dunlop R. L. E., Wormald J. C. R., Jain A. Outcome of surgical repair of adult digital nerve injury: a systematic review. BMJ Open. 2019;13;9(3):e025443. https://doi.org/10.1136/bmjopen-2018-025443
7. Zafeiris T., Heidenreich S., Rödig J. Bifid median nerve as a coincidental finding in traumatology: Case report and review of the literature. Unfallchirurg. 2022;125(5):404-407. https://doi.org/10.1007/s00113-021-01031-5
8. Klimovich P., Rubina K., Sysoeva V., Semina E. New Frontiers in Peripheral Nerve Regeneration: Concerns and Remedies. Int. J. Mol. Sci. 2021;13;22(24):13380. https://doi.org/10.3390/ijms222413380
9. Tang P., Schimoler P. J., Kim H., Gillman B. M., Kharlamov A., Miller M. C. The optimal number and location of sutures in conduit-assisted primary digital nerve repair. J. Hand Surg. (Eur. Vol.) 2018;43(6):621-625. https://doi.org/10.1177/1753193418764290
10. Apablaza J. A., Lezcano M. F., Lopez Marquez A., Godoy Sánchez K., Oporto G. H., Dias F. J. Main Morphological Characteristics of Tubular Polymeric Scaffolds to Promote Peripheral Nerve Regeneration-A Scoping Review. Polymers (Basel). 2021;31;13(15):2563. https://doi.org/10.3390/polym13152563
11. Wang J., Cheng Y., Chen L., Zhu T. [et al.]. In vitro and in vivo studies of electroactive reduced graphene oxide-modified nanofiber scaffolds for peripheral nerve regeneration. Acta Biomater. 2019;15(84):98-113. https://doi.org/10.1016/j.actbio.2018.11.032
12. Shintani K., Uemura T., Takamatsu K. [et al.]. Protective effect of biodegradable nerve conduit against peripheral nerve adhesion after neurolysis. J. Neurosurg. 2018;129(3):815-824. https://doi.org/10.3171/2017.4.jns162522
13. Zorkova A. V., Grigoryeva V. N., Glikin S. E. Surgical treatment of closed intratruncal traumatic injuries of peripheral nerves. Medicinskij Al’manah. – Medical Almanac. 2018;5(56):134-137. (In Russ.). https://doi.org/10.21145/2499-9954-2018-5-134-137
14. Zorkova A. V., Grigoryeva V. N. Neurolysis, endoneural stimulation and artificial epineurium in the surgical treatment of intratruncal injuries of the radial nerve. Prakticheskaja Medicina. – Practical medicine. 2019;17(7):121-126. (In Russ.). https://doi.org/10.32.000/2072-1757-2019-7-121-126
15. Chu X. L., Song X. Z., Li Q., Li Y. R., He F. [et al.]. Basic mechanisms of peripheral nerve injury and treatment via electrical stimulation. Neural. Regen. Res. 2022;17(10):2185-2193. https://doi.org/10.4103/1673-5374.335823
16. Zuo K. J., Gordon T., Chan K. M., Borschel G. H. Electrical stimulation to enhance peripheral nerve regeneration: Update in molecular investigations and clinical translation. Exp. Neurol. 2020;332:113397. https://doi.org/10.1016/j.expneurol.2020.113397
17. Piccinini G., Cuccagna C., Caliandro P. [et al.]. Efficacy of electrical stimulation of denervated muscle: Amulticenter, double-blind, randomized clinical trial. Muscle Nerve. 2020;61:773-778. https://doi.org/10.1002/mus.26880778
18. David S. L., Farnsworth J. L. 2nd, Theige M. Content validity of the disability of the arm, shoulder, and hand questionnaire in a college-age patient population. JSES Int. 2022;22;6(3):512-517. https://doi.org/10.1016/j.jseint.2022.01.014
19. Russel S. M. Examination of Peripheral Nerve Injuries: An Anatomical Approach. Thieme, 2006:178. 20. Aktürk S., Büyükavcı R., Ersoy Y. Median nerve ultrasound in carpal tunnel syndrome with normal electrodiagnostic tests. Acta Neurol. Belg. 2020;120(1):43-47. https://doi.org/10.1007/s13760-018-0963-3

Keywords: traumatic nerve injuries, median nerve, neurolysis, epineural prosthesis, subepineural nerve stimulation


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