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https://doi.org/10.14300/mnnc.2023.18037

T-lymphocytes and morphology of ischemic cutaneous wound of mice within collagen sponge with allogenic dermal fibroblasts transplantation

[Experimental medicine]
Yury Gennadievich Baranovsky; Elena Yuryevna Shapovalova; Tatiana Anatolyevna Boyko; Igor Anatolievich Lugin; Svetlana Vladimirovna Harchenko; Alexey Gennadievich Baranovsky; Anatoly Vladimirovich Kubyshkin;

The problem of healing long-term skin defects, complicated by venous insufficiency, remains a problem despite many known treatments. The article researches immunological compatibility and efficiency of the use of collagen sponges with skin allogeneic fibroblasts for stimulation of wound healing. Sixteen mature C57/B1 mice were divided into two equal groups: control and experimental. In the 10th-day dynamic, the stimulation method was found to be highly effective by associating the collagen sponge with the allofibroblasts, which allows a significant improvement in the morphological characteristics of the sample biopsy and does not cause an autoimmune response to the transplant.

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Keywords: ишемизированная рана кожи, коллагеновая губка, фибробласты, Т-лимфоциты