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https://doi.org/10.14300/mnnc.2023.18036

Correction of ischemic reperfusion liver damage in the experiment with the use of antioxidant drugs

[Experimental medicine]
Konstantin Popov; Ilya Bykov; Igor Tsymbalyuk; Mikhail Bykov;

The article assesses the effectiveness of correction of ischemic reperfusion damage to the liver of rats in an experiment. The study was conducted in 2 groups: the 1st group (n=15) of rats, which were intraperitoneally injected with 2 ml of physiological solution one day before the modeling of the pathological process and immediately before it; 2nd group (n=15) of rats were administered 2 ml of Remaxol and ascorbic acid 20 mg/ml with lipoic acid 3 mg/ml according to a similar scheme. Partial ischemia was simulated for 40 minutes, followed by a 3-hour reperfusion period. Lower markers of cytolic syndrome in rat blood plasma, higher antioxidant activity of blood plasma, and adequate prooxidant-antioxidant balance in liver tissues accompanied antioxidant correction. In rats of the 1st group, the decrease in the level of glutathione in the postischemic tissue relative to the intact tissue was 44 %, and in rats of the 2nd group, it was 18 %. In the 2nd group, the intact parenchyma of the liver showed a lower concentration of glutathione but higher in the damaged lobes than in the 1st group rats. The study’s results show the critical role of intact parenchyma of the liver without vascular exception in compensating for reperfusion changes in post-ischemic tissue. There are also opportunities to improve approaches to the correction of liver damage through combined antioxidant drugs or regimes of administration

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References:
1. Zang X., Zhou J., Zhang X., Han Y., Chen X. Ischemia Reperfusion Injury: Opportunities for Nanoparticles. ACs Biomater. sci. Eng. 2020;6(12):6528-6539. https://doi.org/10.31857/S0006302920060198
2. Popov К. А., Bykov I. М., Tsymbalyuk I. Y., Kurzanov A. N., Storozhuk A. P. [et al.] Changes in the membrane potential of mitochondria in dependence on the continuance of ischemia and reperfusion of liver in rats. Meditsinskii vestnik severnogo Kavkaza. – Medical News of North Caucasus. 2019.14(1):231-235. https://doi.org/10.14300/mnnc.2019.14022
3. Wu G., Chen M., Wang X., Kong E., Yu W. [et al.] Effect of remote ischemic preconditioning on hepatic ischemia-reperfusion injury in patients undergoing liver resection: a randomized controlled trial. Minerva Anestesiol. 2020;86(3):252-260. https://doi.org/10.23736/S0375-9393.19.13838-2
4. Covington S. M., Bauler L. D., Toledo-Pereyra L. H. A The rapeutic Target in Hepatic Ischemia-Reperfusion Injury. J. Invest. surg. 2017;30(1):47-55. https://doi.org/10.1080/08941939.2016.1206999
5. Liao N., Shi Y., Wang Y., Liao F., Zhao B. [et al.] Antioxidant preconditioning improves therapeutic outcomes of adipose tissue-derived mesenchymal stem cells through enhancing intrahepatic engraftment efficiency in a mouse liver fibrosis model. stem. Cell. Res. Ther. 2020;11(1):237. https://doi.org/10.1186/s13287-020-01763-y
6. Nakazato P. C. G., Victorino J. P., Fina C. F., Mendes K. D. S., Gomes M. C. J. [et al.] Liver ischemia and reperfusion injury. Pathophysiology and new horizons in preconditioning and therapy. Acta Cir. Bras. 2018;33(8):723-735. https://doi.org/10.1590/s0102-865020180080000008
7. Pritulina Y. G., Prokopenko S. E., Kordenko A. A., Atiakshin D. A., Lobanov V. L. Evaluation of the effect of Remaxol on hepatocytes in non-alcoholic fatty liver dystrophy modeling in laboratory C57BL/6 mice. Arhiv Patologii. – Arkh Patol. 2019;81(5):64-69. https://doi.org/10.17116/patol20198105164
8. Moreira P. I., Sayre L. M., Zhu X., Nunomura A., Smith M. A. [et al.] Detection and localization of markers of oxidative stress by in situ methods: application in the study of Alzheimer disease. Methods Mol. Biol. 2010;610:419-34. https://doi.org/10.1007/978-1-60327-029-8_25
9. Popov К. А., Bykov I. М., Tsymbalyuk I. Yu., Bykov М. I., Sidorenko A. N. [et al.] Changes in state of the thiol linkages of an antioxidant system during ischemia and reperfusion, against a background of vascular exclusion in the rat liver. Med. News North Cauc. 2018;13(3):525-529. https://doi.org/10.14300/mnnc.2018.13096
10. Mantelou A. G., Zacharioudaki A., Pappas-Gogos G., Papalois A., Papoudou-Bai A. [et al.] Description of a recovery model in rabbits for the study of the late phase of liver ischemia-reperfusion injury. In Vivo. 2022;36(1):153-160. https://doi.org/10.21873/invivo.12686
11. Yasojima E. Y., Domingues R. J. S., Silva R. C., Sousa L. F. F., Trindade Júnior S. C. Comparison of remote and local postconditioning against hepatic ischemic-reperfusion injury in rats. Acta Cir. Bras. 2021;36(1):e360101. https://doi.org/10.1590/ACB360101
12. Hyatt J. R., Zhang S., Akoh C. C. Comparison of antioxidant activities of selected phenolic compounds in O/Wemulsions and bulk oil. Food Chem. 2021;349:129037. https://doi.org/10.1016/j.foodchem.2021.129037
13. Nilsson J., Pillai D., Onning G., Persson C., Nilsson A. [et al.] Comparison of the 2,2’-azinobis-3-ethylbenzotiazo-line-6-sulfonic acid (ABTS) and ferric reducing anti-oxidant power (FRAP) methods to assess the total antioxidant capacity in extracts of fruit and vegetables. Mol. Nutr. Food Res. 2005;49(3):239-46. https://doi.org/10.1002/mnfr.200400083
14. Martín-Fernández M., Aller R., Heredia-Rodríguez M., Gómez-Sánchez E., Martínez-Paz P. [et al.] Lipid peroxidation as a hallmark of severity in COVID-19 patients. Redox. Biol. 2021;48:102181. https://doi.org/10.1016/j.redox.2021.102181

Keywords: ischemia, reperfusion, ischemia-reperfusion syndrome, antioxidants, oxidative stress, energotropic agents