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Dynamics of pathomorphological changes of the heart and lungs in hypercatecholaminemia in white rats
[Experimental medicine]
Vadim Igorevich Demidov; Tatiana Mikhailovna Nikolaeva; Maxim Leonidovich Kasyanik; Anastasia Sergeevna Ivanova;
The dynamics of pathomorphological changes in the heart and lungs of rats with a single injection of adrenaline at a dose of 2 mg/kg of body weight subcutaneously, followed by withdrawal from the experiment after 1 hour, 24 hours, 72 hours. In the created model of catecholamine myocardial injury, the changes are similar to the pathomorphological picture of acute coronary syndrome. The most significant changes were detected in the subendocardial myocardium of the left ventricle,which may be associated with functional overstrain in conditions of insufficient intramural blood supply to cardiomyocytes. Lung changes are characterized by bronchospasm and arteriospasm, stroma edema. These violations persist throughout the entire observation period.
References:
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Keywords: myocardium, lungs, adrenaline, heart, morphometry
Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy