• Main page
• About the journal
• Editorial board
• Subscription
• Information for contributors
• Editorial and Peer Review
• Issues archive
• Authors
• Articles
  • By alphabet
  • By category
• Blogs and comments

The journal is included into The list of leading scientific periodicals.

The journal is included into VINITI database and is registered in Electronic scientific library.

The journal is indexed by SCOPUS, Ulrich's International Periodicals Directory.

EBSCO

https://doi.org/10.14300/mnnc.2022.17112

Modern methods of chondroplasty and possibilities of stimulation of regenerative processes of articular cartilage (Part 2)

[Reviews]
Vladimir Ivanovich Telpukhov; Andrey Vladimirovich Garkavi; Andrey Stanislavovich Chagin; Alexey Vladimirovich Lychagin; Olesya V. Kytko; Kirill Alexandrovich Zhandarov; Pyotr Vyacheslavovich Panyushkin; Shabnam Ildyrim kyzy Ibragimova;

In the second part of the review, various options for the use of cell therapy for the repair of cartilage defects are discussed. The chronological order describes the origin, development and current state of the application of various cellular technologies to stimulate the regenerative processes of articular cartilage based on autologous chondrocytes and mesenchymal stem cells. The analysis and evaluation of the main commercial products of cell engineering used worldwide in clinical practice, in a comparative aspect with alternative surgical approaches, is carried out. Historical and current data on the possibility of using stem cells from various sources for chondroplasty are presented. New promising directions in the development of regenerative technologies and the creation of an «ideal» cell-tissue engineering structure are reflected and outlined.

Download

References:
1. Pestka J. M., Feucht M. J., Porichis S., Bode G., Südkamp N. P. [et al.]. Return to Sports Activity and Work After Autologous Chondrocyte Implantation of the Knee: Which Factors Influence Outcomes? Am. J. Sports Med. 2016;44(2): 370-777. https://doi.org/10.1177/0363546515614578
2. Bozhokin M. S., Bozhkova S. A., Netylko G. I. Possibilities of modern cellular technologies for the restoration of damaged articular cartilage (analytical review of the literature). Travmatologiya i ortopediya Rossii. – Traumatology and Orthopedics of Russia. 2016;3:122-134. (In Russ). https://doi.org/10.21823/2311-2905-2016-22-3-122-134
3. Knee surgery. Ed. Miller M. D. 2nd ed. Elsevier, 2018.
4. Grevenstein D., Mamilos A., Schmitt V. H., Niedermair T., Wagner W. [et al.]. Excellent histological results in terms of articular cartilage regeneration after spheroid-based autologous chondrocyte implantation (ACI). Knee Surg. Sports Traumatol. Arthrosc. 2021;29(2):417-421. https://doi.org/10.1007/s00167-020-05976-9
5. Zeinalov V. T., Shkuro K. V. Methods of treatment of osteochondral injuries of the talus bone (dissecting osteoarthritis) at the present stage (literature review). Kafedra travmatologii i ortopedii. – Department of Traumatology and Orthopedics. 2018;4(34):24-36. (In Russ). https://doi.org/10.17238/issn2226-2016.2018.4.24-36
6. Li X., Li S., Qian J., Chen Y., Zhou Y, Fu P. [et al]. Early Efficacy of Type I Collagen-Based Matrix-Assisted Autologous Chondrocyte Transplantation for the Treatment of Articular Cartilage Lesions. Front. Bioeng. Biotechnol. 2021;28(9):760179. https://doi.org/10.3389/fbioe.2021.760179
7. Brittberg М., Recker D., Ilgenfritz J., SarD B. F. Matrix-applied characteristic autologous cultured chondrocytes versus micro-destruction: a five-year follow-up to a prospective randomized trial. Am. J. Sports Med. 2018;46(6):0363546518756976. https://doi.org/10.1177/0363546518756976
8. Knutsen G., Drogset J. O., Engebretsen L., Grøntvedt T., Ludvigsen T. C. [et al.]. A randomized multicenter study comparing autologous chondrocyte implantation with microfracture. J. Bone Joint Surg. 2016;98:1332-1339. https://doi.org/10.2106/JBJS.15.01208
9. Mao Y., Hoffmann T., Wu A., Cohn J. An innovative laboratory procedure for chondrocyte dilation with reduced dedifferentiation. Cartilage. 2017;9:202-211. https://doi.org/10.1177/1947603517746724
10. Krajewska-Włodarczyk M., Owczarczyk-Saczonek A., Placek W., Osowski A., Wojtkiewicz J. Articular Cartilage Aging-Potential Regenerative Capacities of Cell Manipulation and Stem Cell Therapy. Int. J. Mol. Sci. 2018;19(2):623. https://doi.org/10.3390/ijms19020623
11. Gossla E., Bernhardt A., Tonndorf R., Aibibu D., Cherif Ch. [et al.]. Anisotropic Chitosan Scaffolds Generated by Electrostatic Flocking Combined with Alginate Hydrogel Support Chondrogenic Differentiation. Int. J. Mol. Sci. 2021;22(17):9341. https://doi.org/10.3390/ijms22179341
12. Hu X., Zhang W., Li X., Zhong D., Li Y. [et al.]. Strategies to Modulate the Redifferentiation of Chondrocytes. Front. Bioeng. Biotechnol. 2021;9:764193. https://doi.org/10.3389/fbioe.2021.764193
13. Davies R. L., Kuiper N. J. Regenerative Medicine: A Review of the Evolution of Autologous Chondrocyte Implantation (ACI) Therapy. Bioengineering (Basel). 2019;6(1):22. https://doi.org/10.3390/bioengineering6010022
14. Körner D., Gonser Chr. E., Döbele S., Konrads Chr., Springer F. [et al.]. Matrix-associated autologous chondrocyte implantation with autologous bone grafting of osteochondral lesions of the talus in adolescents: patient-reported outcomes with a median follow-up of 6 years. J. Orth. Surg. Res. 2021;16:243. https://doi.org/10.1186/s13018-021-02384-8
15. Huang B. J., Hu J. C., Athanasiou K. A. Cell-based tissue engineering strategies used in the clinical repair of articular cartilage. Biomaterials. 2016;98:1-22. https://doi.org/10.1016/j.biomaterials.2016.04.018
16. Basok Yu. B., Sevastyanov V. I. Technologies of tissue engineering and regenerative medicine in the treatment of joint cartilage tissue defects. Vestnik transplantologii i iskusstvennykh organov. – Bulletin of Transplantology and Artificial Organs. 2016;XVIII(4):102-122. (In Russ.). https://doi.org/10.15825/1995-1191-2016-4-102-122
17. Jiang S., Guo W., Tian G., Luo X., Peng L. [et al.]. Clinical Application Status of Articular Cartilage Regeneration Techniques: Tissue-Engineered Cartilage Brings New Hope. Stem Cells Int. 2020;2020:ID 5690252. https://doi.org/10.1155/2020/5690252
18. Anderson D. E., Williams III R. J., DeBerardino T. M. Magnetic resonance imaging characterization and clinical outcomes after NeoCart surgical therapy as a primary reparative treatment for knee cartilage injuries. Am. J. Sports Med. 2016;45(4):875-883. https://doi.org/10.1177/0363546516677255
19. Niethammer T. R., Holzgruber M., Gülecyüz M. F., Weber P. Pietschmann M. F. [et al.]. Matrix based autologous chondrocyte implantation in children and adolescents: a match paired analysis in a follow-up over three years post-operation. Int. Orthopaedics. 2017;41(2):343-350. https://doi.org/10.1007/s00264-016-3321-1
20. Albrecht C., Tichy B., Nhrnberger S., Hosiner S., Zak L. [et al.]. Gene expression and cell differentiation in matrix-associated chondrocyte transplantation grafts: a comparative study. Osteoarthritis Cartilage. 2011;19(10):1219- 1227. https://doi.org/10.1016/j.joca.2011.07.004
21. Fitzsimmons R. E. B., Mazurek M. S., Soos A., Simmons C. A. Mesenchymal Stromal/Stem Cells in Regenerative Medicine and Tissue Engineering. Stem Cells Int. 2018;2018:ID8031718. https://doi.org/10.1155/2018/8031718
22. Ward M. R., Abadeh A., Connelly K. A. Concise Review: Rational Use of Mesenchymal Stem Cells in the Treatment of Ischemic Heart Disease. Stem Cells Transl. Med. 2018;7(7):543-550. https://doi.org/10.1002/sctm.17-0210
23. Li L., Duan X., Fan Z. Mesenchymal stem cells in combination with hyaluronic acid for articular cartilage defects. Sci. Rep. 2018;8(1):9900. https://doi.org/10.1038/s41598-018-27737-y
24. Airapetov G. A., Vorotnikov A. A., Konovalov E. A. Methods of surgical treatment of local defects of hyaline cartilage of large joints (literature review). Geniy ortopedii. – The genius of orthopedics. 2017;23(4):485-491. (In Russ.). https://doi.org/10.18019/1028-4427-2017-23-4-485-491
25. Nurul A. A., Azlan M., Ahmad Mohd Zain M. R., Sebastian A. A., Fan Y. Z. [et al.]. Mesenchymal Stem Cells: Current Concepts in the Management of Inflammation in Osteoarthritis. Biomedicines. 2021;9(7):785. https://doi.org/10.3390/biomedicines9070785
26. Thompson S. D., Pichika R., Lieber R. L., Lavasani M. Systemic transplantation of adult multipotent stem cells prevents articular cartilage degeneration in a mouse model of accelerated ageing. Immun. Ageing. 2021;18(1):27. https://doi.org/10.1186/s12979-021-00239-8
27. Pak J., Lee J. H., Pak N. J., Park K. S., Jeon J. H. Clinical Protocol of Producing Adipose Tissue Derived Stromal Vascular Fraction for Potential Cartilage Regeneration. J. Visual. Exp. 2018;139:e58363. https://doi.org/10.3791/58363
28. Pers Y. M., Rackwitz L., Ferreira R., Pullig O., Delfour C. [et al.]. ADIPOA Consortium. Adipose Mesenchymal Stromal Cell-Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose-Escalation Trial. Stem Cells Transl. Med. 2016;5(7):847-856. https://doi.org/10.5966/sctm.2015-0245
29. Yao Fu, Lisanne Karbaat, Ling Wu, Jeroen Leijten, Sanne K. Both, Marcel Karperien. Trophic Effects of Mesenchymal Stem Cells in Tissue Regeneration. Tissue Engineering Part B: Reviews. 2017;23(6):515-528. https://doi.org/10.1089/ten.teb.2016.0365
30. Volarevic V., Markovic B. S., Gazdic M., Volarevic A., Jovicic N. [et al.]. Ethical and Safety Issues of Stem CellBased Therapy. Int. J. Med. Sci. 2018;15(1):36-45. https://doi.org/10.7150/ijms.21666
31. Park Y. B., Ha C. W., Lee C. H., Yoon Y. C., Park Y. G. Cartilage Regeneration in Osteoarthritic Patients by a Composite of Allogeneic Umbilical Cord Blood-Derived Mesenchymal Stem Cells and Hyaluronate Hydrogel: Results from a Clinical Trial for Safety and Proof-of-Concept with 7 Years of Extended Follow-Up. Stem Cells Transl. 2017;6(2):613-621. https://doi.org/10.5966/sctm.2016-0157
32. Zhang Y., Liu S., Guo W., Wang M., Hao C. [et al.]. Human umbilical cord Wharton’s jelly mesenchymal stem cells combined with an acellular cartilage extracellular matrix scaffold improve cartilage repair compared with microfracture in a caprine model. Osteoarthritis Cartilage. 2018;26(7):954-965. https://doi.org/10.1016/j.joca.2018.01.019
33. Sadlik B., Jaroslawski G., Puszkarz M., Blasiak A., Oldak T. [et al.]. Cartilage Repair in the Knee Using Umbilical Cord Wharton’s Jelly-Derived Mesenchymal Stem Cells Embedded Onto Collagen Scaffolding and Implanted Under Dry Arthroscopy. Arthrosc. Tech. 2017;7(1):57-63. https://doi.org/10.1016/j.eats.2017.08.055
34. Jia Z., Zhu F., Li X., Liang Q., Zhuo Z. [et al.]. Repair of osteochondral defects using injectable chitosan-based hydrogel encapsulated synovial fluid-derived mesenchymal stem cells in a rabbit model. Mater. Sci. Eng. C. 2019;99:541- 551. https://doi.org/10.1016/j.msec.2019.01.115
35. Vinod E., Padmaja K., Ramasamy B., Sathishkumar S. Systematic review of articular cartilage derived chondroprogenitors for cartilage repair in animal models. J. Orthop. 2022;35:43-53. https://doi.org/10.1016/j.jor.2022.10.012
36. Li L., Newton P. T., Bouderlique T., Seinokhova M., Zikmund T. [et al.]. Surface cells – self-healing precursors of chondrocytes that form articular cartilage in young mice. FASEB J. 2017;31(3):1067-1084. https://doi.org/10.1096/fj.201600918R
37. Ko J. Y., Im G. I. Chondrogenic and osteogenic induction from iPS cells. Met. Mol. Biol. 2016;1357:441-450. https://doi.org/10.1007/7651_2014_136
38. Luo Y., Gao D., Wang P., Lou C., Li T. [et al.]. Optimized culture methods for isolating small extracellular vesicles derived from human induced pluripotent stem cells. J. Extracell. Vesicles. 2021;10(6):e12065. https://doi.org/10.1002/jev2.12065
39. Mandai M., Watanabe A., Kurimoto Y., Hirami Y., Morinaga C. [et al.]. Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration. N. Engl. J. Med. 2017;376:1038-1046. https://doi.org/10.1056/NEJMoa1608368

Keywords: articular cartilage, osteoarthritis, cartilage regeneration, autochondrocytes, stem cells