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https://doi.org/10.14300/mnnc.2022.17098

The cardioprotective effect of 3-formylchromone derivatives. Focus on changes in the functional activity of mitochondria

[Original research] [Clinical Pharmacology] [Pharmacology]
Dmitry Pozdnyakov; Ilya E. Rybalko; Kristina Khorenovna Sarkisyan;

Проведено изучение кардиопротекторной активности шести новых производных 3-формилхромона в сравнении с триметазидином и мельдонием при курсовом терапевтическом пероральном введении в условиях экспериментального инфаркта миокарда. Установлено, что применение производных 3-формилхромона увеличивает активность цитратсинтазы и соответственно метаболическую активность интерфибриллярных митохондрий, подавляя при этом образование супероксид-радикала в субсарколеммальных митохондриях, уменьшая зону некроза миокарда

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Keywords: myocardial infarction, 3-formylchromone derivatives, mitochondrial dysfunction, cardioprotection