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ISSN 2073-8137
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The effect of the drugs with GABA-ergic effect on body weight, glucose tolerance and insulin resistance in obese mice

[Original research] [Clinical Pharmacology] [Pharmacology]
Ivan Nikolaevich Tyurenkov; Denis V. Kurkin; Dmitry Aleksandrovich Bakulin; Marina Aleksandrovna Dubrovina; Elizaveta Evgenievna Abrosimova; Nikolay Sergeevich Kovalev; Vladimir Ivanovich Petrov;

The article presents the results of assessing the effect of GABA and its derivatives on the metabolic state of mice kept on a high-calorie diet for 6 months. It was found that oral administration of aminalon for 4 weeks reduced body weight and improved the glucose utilization rate. The results obtained provide a basis for the search and development of drugs for the correction of carbohydrate metabolism disorders based on agonists of GABA-A and GABA-B receptors.

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Keywords: obesity, diabetes, high-calorie diet, GABA


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Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy