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https://doi.org/10.14300/mnnc.2022.17096

The experimental justification of the drug effectiveness for the local treatment of the joints inflammatory diseases on the model of klebsiella-candida arthritis

[Original research] [Clinical Pharmacology] [Pharmacology]
Olga Efimovna Chelpachenko; Andrey Fisenko; Александр Абрамович Стадников; Elena Valeryevna Ivanova; Natalia Borisovna Perunova;

The study was carried out to determine the effectiveness of the developed drug for the local treatment of inflammatory joint disease with the code name «Linisdic hydrogel» (LH) containing lincomycin hydrochloride, nystatin, diclofenac natrii based on organosilicon glycerohydrogel with high transcutaneous activity, an experimental model of infectious arthritis (Klebsiella Candida) was reproduced in vivo in Wistar rats. Comparative characterization was carried out with Voltaren emulgel (VE). The dynamics of macroscopic and morphological changes in the joints during treatment with these drugs showed the advantage of «LH» in anti-inflammatory and reparative effects compared with VE, which indicates the need for further testing of this drug in clinical conditions in order to use it for effective local treatment of inflammatory joint diseases.

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Keywords: local treatment, joints, experimental model in vivo, Klebsiella-Candida arthritis