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https://doi.org/10.14300/mnnc.2022.17089

Influence of proatherogenic factors and genetic thrombophilia on severity of coronary lesion in young patients with myocardial infarction type 1

[Original research] [Internal diseases]
Natalia Gladkikh; Alena Safronova Shushanova; Alexandr Yagoda;

Relationship of atherosclerosis risk factors, dyslipidemia and genetic thrombophilia with severity of coronary artery disease in 100 young patients with myocardial infarction (MI) type 1 was studied. According to multivariate analysis, number of atherosclerosis risk factors, low-density lipoproteins and combination of heterozygous genotypes of integrin β3 (ITGB3: 1565T/C) and inhibitor of plasminogen activator type 1 (PAI-1: –675 5G/4G) genes have an independent effect on formation of severity of coronary lesion.

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Keywords: myocardial infarction, atherosclerosis, genetic thrombophilia, young age, men