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ISSN 2073-8137

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Influence of proatherogenic factors and genetic thrombophilia on severity of coronary lesion in young patients with myocardial infarction type 1

[Original research] [Internal diseases]
Natalia Gladkikh; Alena Safronova Shushanova; Alexandr Yagoda;

Relationship of atherosclerosis risk factors, dyslipidemia and genetic thrombophilia with severity of coronary artery disease in 100 young patients with myocardial infarction (MI) type 1 was studied. According to multivariate analysis, number of atherosclerosis risk factors, low-density lipoproteins and combination of heterozygous genotypes of integrin β3 (ITGB3: 1565T/C) and inhibitor of plasminogen activator type 1 (PAI-1: –675 5G/4G) genes have an independent effect on formation of severity of coronary lesion.


1. Yakushin S.S. Mnogolikij infarkt miokarda: rukovodstvo. M.: «GEOTAR-Media», 2022. (In Russ.). https://doi.org/10.33029/9704-6421-2-INF-2022-1-232
2. Averkova A. O., Brazhnik V. A., Rogozhina A. A., Evdokimova M. A., Koroleva O. S. [et al.]. Family history of cardiovascular disease in patients with early development of acute coronary syndrome. Kardiologiya. – Cardiology. 2018;58(8):12-17. (In Russ.). https://doi.org/10.18087/cardio.2018.8.10158
3. Ponomarenko I. V., Sukmanova I. A. Thrombosis risk factors and gene mutations in young age patients with acute coronary syndrome. Kardiologiya. – Cardiology.2019;59(1S):19-24. (In Russ.). https://doi.org/10.18087/cardio.2602
4. Brænne I., Kleinecke M., Reiz B., Graf E., Strom T. [et al.]. Systematic analysis of variants related to familial hypercholesterolemia in families with premature myocardial infarction. Eur. J. Hum. Genet. 2016;24(2):191-197. https://doi.org/10.1038/ejhg.2015.100
5. Ellis K. L., Pang J., Schultz C. J., Watts G. F. New data on familial hypercholesterolaemia and acute coronary syndromes: The promise of PCSK9 monoclonal antibodies in the light of recent clinical trials. Eur. J. Prev. Cardiol. 2017;24(11):1200-1205. https://doi.org/10.1177/2047487317708890
6. Alekseeva E. V., Gordeeva S. V., Rudomanova V. V., Ivanchura G. S. Myocardial infarction in young age. Nauchnyj vestnik zdravoohraneniya Kubani. – Scientific Bulletin of Kuban Healthcare. 2019;62(2):1-11. (In Russ.).
7. Shesternya P.A., Nikulina S.Yu., Shulman V.A., Martynova E. A., Demkina A. I. [et al.]. Genetic predictors of myocardial infarction in subjects of young age. Kardiologiya. – Cardiology. 2013;53(7):4-8. (In Russ.).
8. Yunyun W., Tong L., Yingwu L., Bojiang L., Yu W. [et al.]. Analysis of risk factors of ST-segment elevation myocardial infarction in young patients. BMC Cardiovasc. Disord. 2014;14:179. https://doi.org/10.1186/1471-2261-14-179
9. Kozhanova T. V., Neudakhin E. V., Zhilina S. S., Mescheryakova T. I., Abramov A. A. [et al.]. The genetic susceptibility to atherosclerosis. Arhiv vnutrennej mediciny. – The Russian Archives of Internal Medicine. 2018;8(6):407-417. (In Russ.). https://doi.org/10.20514/2226-6704-2018-8-6-407-17
10. Roy H., Bhardwaj S., Yla-Herttuala S. Molecular genetics of atherosclerosis. Hum. Genet. 2009;125(5-6):467-491. https://doi.org/10.1007/s00439-009-0654-5
11. Chiasakul T., De Jesus E., Tong J., Chen Y., Crowther M. [et al.]. Inherited thrombophilia and the risk of arterial ischemic stroke: a systematic review and meta-analysis. J. Am. Heart Assoc. 2019;8(19):e012877. https://doi.org/10.1161/JAHA.119.012877
12. Rukavitsyn O. A. Gematologiya: nacional’noe rukovodstvo. M.: «GEOTAR-Media», 2019. (In Russ.).
13. Pavlova T. V., Poliakov V. P., Dupliakov D. V., Khokhlunov S. M., Kirillov V. I., Shavkunov S. A. Distributions of polymorphisms of genes of some components of hemostasis in patients with ischemic heart disease. Kardiologiya. – Cardiology.2009;49(4):9-13. (In Russ.).
14. Fedorova S. B., Kulagina I. V., Ryabov V. V. Hemostatic gene polymorphisms in acute coronary syndrome with nonobstructive coronary atherosclerosis. Kardiologiya. – Cardiology. 2019;59(10):14-22. (In Russ.). https://doi.org/10.18087/cardio.2019.10.2680
15. Alkhiary W., Azzam H., Yossof M. M., Aref S., Othman M., El-Sharawy S. Association of hemostatic gene polymorphisms with early-onset ischemic heart disease in Egyptian patients. Clin. Appl. Thromb. Hemost. 2016;22(6):535-542. https://doi.org/10.1177/1076029615572466
16. Boroumand M., Pourgholi L., Ziaee S., Anvari M. S., Jalali A., Goodarzynejad H. The association between Factor V Leiden with the presence and severity of coronary artery disease. Clin. Biochem. 2014;47(6):356-360. https://doi.org/10.1016/j.clinbiochem.2013.12.006
17. Fajar J. K. The β fibrinogen gene G-455A polymorphism in Asian subjects with coronary heart disease: A meta-analysis Egypt. J. Med. Hum. Genet. 2017;18:19-28. https://doi.org/10.1016/j.ejmhg.2016.06.002
18. Lewandowski K., Kwaśnikowski P., Elikowski W., Zawilska K. Myocardial infarction in patients aged less than 40 years. Frequency of BclI polymorphism in the fibrinogen β-chain gene and plasma fibrinogen. Kardiologia Polska (Polish Heart Journal). 2003;59(9):209-211.
19. Pourgholi L., Goodarzynejad H., Ziaee S., Zare E., Jalali A., Boroumand M. Prothrombin gene G20210A variant in angiographically documented patients with coronary artery stenosis. J. Tehran Heart Cent. 2019;14(4):150-155.
20. Ostryj infarkt miokarda s podemom segmenta ST elektrokardiogrammy. Klinicheskie rekomendacii MZ RF. М., 2020. (In Russ.).
21. Diagnostics and correction of lipid metabolism disorders in order to prevent and treat of atherosclerosis. Russian recommendations, VII revision. Ateroskleroz i dislipidemii. – Atherosclerosis and dyslipidemia. 2020;38(1):7-42. (In Russ.). https://doi.org/10.34687/2219-8202.JAD.2020.01.0002
22. Grigor’ev V. S., Petrosyan K. V., Abrosimov A. V. Anatomical SYNTAX Score: a tool for coronary artery disease severity assessment and predicting endovascular treatment outcomes. Kreativnaya kardiologiya. – Creative Cardiology. 2019;13(2):159-172. (In Russ.). https://doi.org/10.24022/1997-3187-2019-13-2-159-172
23. Guerrero-Pinedo F., Ochoa-Zárate L., Salazar C. J., Carrillo-Gómez D. C., Paulo M. [et al.]. Association of traditional cardiovascular risk factors in adults younger than 55 years with coronary heart disease. Case-control study. SAGE Open Med. 2020;8:2050312120932703. https://doi.org/10.1177/2050312120932703
24. Oganov R. G. Dislipidemii i ateroskleroz. Biomarkery, diagnostika i lechenie: rukovodstvo dlya vrachej. M.: «GEOTAR-Media», 2009. (In Russ.).
25. Sumarokov A. B., Buryachkovskaya L. I. Junion junction in mechanisms action drugs in hypolipidemic and antithrombotic therapies. Review. Ateroskleroz i dislipidemii. – Atherosclerosis and dyslipidemia. 2021;42(1):5-20. (In Russ.). https://doi.org/10.34687/2219-8202.JAD.2021.01.0001

Keywords: myocardial infarction, atherosclerosis, genetic thrombophilia, young age, men

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy