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https://doi.org/10.14300/mnnc.2022.17077

Analysis of two cases of consecutive use of plasma -derived an d recombinant coagulation factors for intensive care in massive obstetric hemorrhage

[Notes from practice]
Alexander Valeryevich Kuligin; Alexander Vladimirovich Lushnikov; Zeulina Ekaterina E.;

Massive obstetric hemorrhage (MOH) is a life-threatening complication of pregnancy and childbirth, as well as the early postpartum period. MOH is one of the triad of major causes of maternal mortality, both in the world and in our country. in the coagulopathy intensive therapy, as a clinical manifestation of MOH, plasma and recombinant concentrates of blood coagulation factors are used with good effect, which include, respectively, the concentrate of the prothrombin complex «Protromplex 600» and the recombinant factor (rFVIIa) «Coagil-VII». The authors analyze two clinical cases of the effective sequential use of the above factors of the blood coagulation system in the complex treatment of a coagulopathic state in women with MOH caused by an abnormal location of the placenta and amniotic fluid embolism.

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Keywords: massive obstetric hemorrhage, coagulopathy, recombinant and plasma concentrates of blood coagulation factors