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ISSN 2073-8137

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Use of confocal microscopy of the cornea as an early marker of sensory neuropathy in patients with metabolic syndrome

Victoria Gennadievna Osepyants; Sergei Karpov; Galina Saneeva; Nina Lvovna Cherednichenko;

Using confocal microscopy of the eye cornea, we studied the prevalence of distal polyneuropathy and assessed the relationship between the severity of its manifestations and the degree of impaired carbohydrate metabolism in 41 patients with obesity, pre-diabetic dysglycemia, and type 2 diabetes mellitus (DM). Deviations from the norm of the coefficients of anisometropy and asymmetry, directly correlating with the indicators of glycemia, are reliably often established. Comparable values of the asymmetry coefficient in patients with type 2 DM and prediabetes allow us to consider it as a predictor of the onset or early marker of dysmetabolic polyneuropathy.


1.Nedosugova L. V. Pathogenesis, clinical manifestations, approaches to the treatment of diabetic polyneuropathy. Meditsinsky sovet. – Medical advice. 2013;12:43-49. (In Russ.). https://doi.org/10.21518/2079-701X-2013-12-43-49
2. Boulton A. J. M., Vileikyte L. Painful diabetic neuropathy in clinical practice. Springer, London. 2011. https://doi.org/10.1007/978-0-85729-488-3
3. Hertz P., Bril V., Orszag A., Ahmed A., Ng E. [et al.]. Reproducibility of in vivo corneal confocal microscopy as a novel screening test for early diabetic sensorimotor polyneuropathy. Diabet. Med. 2011;28(10):1253-1260. https://doi.org/10.1111/j.1464-5491.2011.03299.x
4. Guerrero-Moreno A., Baudouin Ch., Parsadaniantz S. M., Goazigo A. R. Morphological and functional changes of corneal nerves and their contribution to peripheral and central sensory abnormalities. Front. Cell. Neurosci. 2020;14:610342. https://doi.org/10.3389/fncel.2020.610342

Keywords: neuropathy, metabolic syndrome, confocal microscopy of the cornea of the eye

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy