logo
Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
rus
русский
eng
english

Site search



Correspondence address
310 Mira Street, Stavropol, Russia, 355017

Tel
+7 865 2352511, +7 865 2353229.

E-mail
medvestnik@stgmu.ru

Efficiency of psychopharmaco therapy and probabili ty of adverse reactions in depressive disorders in ethnic populations of the Stavropol region

[Pharmacology]
Svetlana Stepanyan; Eleonora Manvelyan; Vladimir Yarovitsky;

Medical documentation of 320 Slavs, Armenians, Nogais, Karachayevites, Turkmens (46.9 % of men and 53.1 % of women 18–55 years old) with depressive disorder was reviewed. Pharmacotherapy was detected as most effective in Armenians, less effective (descending) in Karachai, Nogai, Turkmen, Slavs. Adverse reactions were more often noted in groups of Armenians and Nogais, less often decreasing in groups of Karachais, Turkmens, most rarely in the group of Slavs.

Download

References:
1. Ferrari A. J., Somerville A. J., Baxter A. J., Norman R., Patten S. B. [et al.]. Global variation in the prevalence and incidence of major depressive disorder: a systematic review of the epidemiological literature. Psychol. Med. 2013;43:471-481. https://doi.org/10.1371/journal.pmed.1001547
2. Shah R. R. Inter-ethnic differences in drug response: Implications for drug development and complying with drug regulation. Clin. Res. Regul. Affairs. 2015;32(3):88-98. https://doi.org/10.3109/10601333.2015.1064131
3. Cazzola M., Calzetta L., Matera M. G., Hanania N. A., Rogliani P. How does race / ethnicity influence the pharmacological outcome of asthma treatment? Exp. Opin. Drug Metabol. Toxicol. 2018;14(4):435-446. https://doi.org/10.1080/17425255.2018.1449833
4. Ferdinand K. C., Igari M. The role of racial/ethnic factors in global clinical trials. Exp. Rev. Clin. Pharmac. 2018;11(9):829-832. https://doi.org/10.1080/17512433.2018.1510311
5. Mirzaev K. B., Fedorinov D. S., Ivashchenko D. V., Sychev D. A. Multi-Ethnic Analysis of Cardiac Pharmacogenetic Markers of Cytochrome P450 and Membrane Transporters Genes in the Russian Population. Racional’naja Farmakoterapija v Kardiologii. – Rational Pharmacotherapy in Cardiology. 2019;15(3):393-406. (In Russ.). https://doi.org/10.20996/1819-6446-2019-15-3-393-406
6. Биполярное аффективное расстройство: диагностика и терапия. Под редакцией С. Н. Мосолова. М.: МЕД-пресс-информ, 2008. [Bipoljarnoe affektivnoe rasstrojstvo: diagnostika i terapija. Pod redakciej S. N. Mosolova. M.: MEDpress-inform, 2008. (In Russ.)].
7. Baturin V. A., Ivanova A. V., Muravyev K. A., Tsarukyan A. A., Kolodyazhnaya E. N. Ethnic characteristics of antiaggregant action of acetylsalicylic acid in residents of Stavropol territory. Meditsinskii vestnik Severnogo Kavkaza. – Medical News of North Caucasus. 2020;15(1):68-71. (In Russ.). https://doi.org/10.14300/mnnc.2020.15015
8. Shacberg A. F., Koul D. O., DeBattista Ch. Rukovodstvo po klinicheskoj psihofarmakologii. M.: MEDpressinform, 2019. (In Russ.).
9. Hronobiologicheskaja terapija affektivnyh rasstrojstv. Рod obshhej redakciej S. N. Mosolova. M.: AVANPORT, 2014. (In Russ.).
10. Grjibovski A. M., Ivanov S. V., Gorbatova M. A. Analysis of nominal and rank transaction data using Statistica and SPSS software. Nauka i Zdravoohranenie. – Science and Health. 2016;6:5-39. (In Russ.).
11. Wichniak A., Wierzbicka A., Walęcka M., Jernajczyk W. Effects of Antidepressants on Sleep. Curr. Psych. Rep. 2017;19(9):63. https://doi.org/10.1007/s11920-017-0816-4
12. Arushanjan Je. B., Baturin V. A., Ovanesov K. B. Osnovy hronomediciny i hronofarmakologii. Stavropol’: StGMU, 2016. (In Russ.).
13. Baturin V. A., Tsarukyan A. A. Genetic polymorphism of cytochrome Р-450 isoenzyme CYP2D6 in population of Stavropol region. Meditsinskii vestnik Severnogo Kavkaza. – Medical News оf North Caucasus. 2013; 8(1):86-87. (In Russ.).
14. Baturin V. A., Tsarukyan A. A., Kolodijchuk E. V. Study of CYP2C9 gene polymorphism n ethnic groups of the population of Stavropol region. Meditsinskii vestnik Severnogo Kavkaza. – Medical News оf North Caucasus. 2014;9(1):45-48. (In Russ.). https://doi.org/10.14300/mnnc.2014.09013
15. Romodanovsky D. P., Khapaev B. A., Ignatiev I. V., Kukes V. G., Karkischenko V. N. Frequencies the «slow» allele variants of the genes coding isoenzymes of cytochrome Р450 CYP2D6, CYP2C19, CYP2C9 in Karachaevs and Circassians. Biomedicina. – Biomedicine. 2010;2:33-37. (In Russ.).
16. Mirzaev K. B., Sychev D. A., Ryzhikova K. A., Konova O. D., Mammaev S. N. [et al.]. Genetic Polymorphisms of Cytochrome P450 Enzymes and Transport Proteins in a Russian Population and Three Ethnic Groups of Dagestan. Gen. Test. Molес. Biomark. 2017;21(12):747-753. https://doi.org/10.1089/gtmb.2017.0036
17. Touma J. A., McLachlan A. J., Gross A. S. The role of ethnicity in personalized dosing of small molecule tyrosine kinase inhibitors used in oncology. Transl. Cancer Res. 2017;6(10):1558-1591. https://doi.org/10.21037/tcr.2017.09.09
18. Ivashchenko D. V., Nasyrova R. F., Ivanov M. V., Neznanov N. G. The history of pharmacogenetics in psychiatry. Farmakogenetika i Farmakogenomika. – Pharmacogenetics and Pharmacogenomics.2015;2:33-40. (In Russ.).

Keywords: the effectiveness of psychopharmacotherapy, side effects, depressive disorder, psychotropic drugs, ethnic groups


Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy