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Autoantibodies to S-100В protein as predictor for severity progression of diabetes mellitus type I in children

[Pediatrics]
Jury Bykov; Tatyana Uglova;

The object of the study was the content of IgG autoantibodies (AAB) to S-100В protein in blood serum in children and teenagers with Diabetes Mellitus Type I. The study involved 76 patients of both sexes aged 1 to 17 years, including 38 children with Type I Diabetes (Group I) and 38 children without diabetes (Group II). It was found that the maximum levels of AAB to S-100В protein were observed in severe cases of Type I Diabetes (Group I). These cases also demonstrated higher levels of glucose: 12.45±1.98 mmol/l and ketone bodies in the urine (160 mg/dl). During the examination, clinical evidence of diabetic ketoacidosis and cerebral edema were observed. In group II, the content of AAB to S-100В protein was within normal range. It is assumed that higher content of AAB to the S-100В protein may be a predictor of children’s brain dysfunction related to long-term Type I Diabetes Mellitus.

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References:
1.Garro A., Chodobski A., Szmydynger-Chodobska J., Shan R., Bialo S. R. [et al.]. Circulating matrix metalloproteinases in children with diabetic ketoacidosis. Pediatr. Diabetes. 2017;18(2):95-102. https://doi.org/10.1111/pedi.12359
2. Bajor M., Zaręba-Kozioł M., Zhukova L., Goryca K., Poznański J. [et al.]. An Interplay of S-Nitrosylation and Metal Ion Binding for Astrocytic S100B Protein. PLoS One. 2016;11(5):e0154822. https://doi.org/10.1371/journal.pone.0154822
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4. Samoilova Yu. G., Novoselova M. V., Kostyunina A. K., Pirmagomedova E. D., Latypova A. V. Predictors of developing encephalopathy in patients with diabetes mellitus. Endokrinologicheskie problemy. – Endocrinology problems. 2013;5(69): 67-71. (In Russ.).
5. Cristóvão J. S., Gomes C. M. S100 Proteins in Alzheimer’s Disease. Front Neurosci. 2019;13:463. https://doi.org/10.3389/fnins.2019.00463
6. Baturin V. A., Bykov Yu. V., Mamceva G. I., Uglova T. I., Baturina M. V. Analysis the level of autoantibodies to dopamine and nmda receptors, S-100 protein, against the background for insulin-dependent diabetes mellitus in children. Rossijskij allergologicheskij zhurnal. – Russian Allergological Journal. 2019;16(1,s.2):34-36. (In Russ.).
7. Ermakov S. V., Mozheiko R. A., Baturin V. A., Belokon O. S. S100 protein autoantibody level as a possible outcome predictor in acute stroke. Vestnik sovremennoi klinicheskoi mediciny. – The Bulletin of Contemporary Clinical Medicine. 2018;11(6):11-15. (In Russ.). https://doi.org/10.20969/VSKM.2018.11(6).11-15

Keywords: Diabetes Mellitus Type I, S-100В protein, autoantibodies