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https://doi.org/10.14300/mnnc.2021.16109

The role of oxidative stress in the pathogenesis of socially significant human diseases and ways of its drug correction

[Reviews]
Yury Olefir; Boris Konstantinovich Romanov; Vladimir Kukes; Dmitry Sychev; Alexey Prokofiev; Olga Konstantinovna Parfenova; Nikita Gennadievich Sidorov; Tatiana Vladimirovna Alexandrova;

The review article describes the role of oxidative stress in the development of socially significant pathologies and approaches to its neutralization. It is shown that the mechanism of oxidative stress is the same in different pathologies, but the consequences of its development may differ. It was found that oxidative stress is one of the main factors in the pathogenesis of severe forms of new coronavirus infection, accompanied by the accumulation of acidic products in the blood and tissues and an increase in the level of Pro-inflammatory cytokines. Various classifications of antioxidant drugs are presented, as well as the pharmacotherapeutic capabilities of domestic low toxic antioxidants: medicinal product containing succinic acid, inosine, nicotinamide and riboflavin, ethyl methyl hydroxypyridine malate and ethyl methyl hydroxypyridine succinate.

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Keywords: oxidative stress, COVID-19, antioxidants, succinic acid, inosine, nicotinamide, riboflavin, ethyl methyl hydroxypyridine malate, ethyl methyl hydroxypyridine succinate