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https://doi.org/10.14300/mnnc.2021.16102

Analysis of changes in redox reactions in intoxication with nickel chloride and the NO-synthase inhibitor

[Abstracts]
Sergey Dzugkoev; Fira Dzugkoeva; Irina Mozhayeva; Olga Marghiev;

Intoxication syndrome was induced by exposure of the nickel chloride and its combination with L-NAME for 30 days in Wistar rats. LPO activity, antioxidant system (AOS), the content of total nitric oxide (NOx) metabolites as well as the activity of membrane enzyme Na+,K+-ATPase in renal, hepatic and myocardial tissue homogenates and the level of organ-specific and excretory plasma enzymes were determined. The data showed intensification of the LPO process and decreased NOx content in blood. Free-radical oxidation in cell membranes of internal organs contributed to their permeability and the level of organ-specific, membrane and excretory enzymes in blood plasma. The activity of Na+,K+-ATPase in organ homogenates decreased. L-arginine administration resulted in increased level of NOx, inhibition of LPO, increased AOS activity and decreased activity of organ-specific enzymes in blood plasma, increase in the activity Na+,K+-ATPase.

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References:
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Keywords: nitric oxide, nickel chloride, endothelial dysfunction