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https://doi.org/10.14300/mnnc.2021.16088

Molecular genetic differentiation of depression in affective pathology and schizophrenia with depressive disorders: the role of polymorphism IL-1β –511C/T

[Psychiatry]
Tatiana Viktorovna Lezheiko; Denis Tikhonov; Vera Cabrael Jello; Marina Vladimirovna Gabaeva; Galina Ivanovna Korovaitseva; Oleg Boev; Vera Evgenievna Golimbet;

In recent years, there have been data indicating differences in the immunological profile of affective disorders in depression and depressive states within various nosologies. The aim of the research was to study the distribution of genotypes by polymorphism –511C/T of the interleukin-1B (IL-1β) gene in patients with depressive disorders within the framework of affective diseases and endogenous diseases of the schizophrenic spectrum. The study included 430 patients who were divided into three groups: the first group (n=142) included patients with depressive episodes within the framework of affective disorders, the second (n=139) – patients with schizophrenia with depressive disorders. The comparison group (n=149) consisted of patients with schizophrenia without depressive disorders. A molecular-genetic study showed that in the group of patients with depression, the frequency of the CC genotype was significantly higher than in the group of patients with schizophrenia with depressive disorders (p=0.004). The results obtained indicate the specificity of the association between polymorphism IL-1β –511C/T and depressive states within the framework of nosologically different disorders.

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Keywords: schizophrenia, depression, pathogenesis, inflammation, polymorphism