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https://doi.org/10.14300/mnnc.2021.16072

Influence of phenazepam, melatonin and their combination on the level of antioxidant enzymes in the forebrain of stressed rats

[Abstracts]
Olga Kaminskaya; Eduard Beyer; Eduard Beyer; Karine Elbekyan; Eduard Arushanyan;

Chronic stress causes changes in the antioxidant system enzymes activity in rat’s brain tissue, indicating an increase in oxidative reactions. Melatonin and Phenazepam (0.5 mg/kg each) similarly attenuate stress-induced shifts. With the joint introduction of substances, their antioxidant effect is markedly enhanced.

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References:
1. Fedoce A. G., Ferreira F., Bota R.G. [et al.]. The role of oxidative stress in anxiety disorder: cause or consequence? Free Radic. Res. 2018;52(7):737-750.
https://doi.org/10.1080/10715762.2018.1475733
2. Yu H. L., Zhang P. P., Zhang C. [et al.]. Effects of rhodiola rosea on oxidative stress and negative emotional states in patients with obstructive sleep apnea. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019;33(10):954-957.
https://doi.org/10.13201/j.issn.1001-1781.2019.10.013
3. Popovic V., Janicijevic-Hudomal S., Kaurinovic B. Antioxidant effects of some drugs on immobilization stress combined with cold restraint stress. Molecules. 2009;14(11):4505-4516.
https://doi.org/10.3390/molecules14114505.3
4. Arushanyan E. B. Limitation of oxidative stress as the main factor of the universal protective properties of melatonin. Eksperimental’naya i klinicheskaya farmakologiya. – Experimental and Clinical Pharmacology. 2012;75(5):44- 49]. (In Russ.).
https://doi.org/10.30906/0869-2092-2012-75-5-44-49
5. Arushanyan E. B., Beyer E. V., Kaminskaya O. V., Sotnikova L. K. Positive aspects of the combined effect of melatonin and phenazepam on the behavioral activity of rats. Meditsinskii vestnik Severnogo Kavkaza. – Medical New of North Caucasus. 2015;10(1):84-87. (In Russ.).
https://doi.org/10.14300/mnnc.2015.10014

Keywords: Phenazepam, Melatonin, oxidative stress