• Main page
• About the journal
• Editorial board
• Subscription
• Information for contributors
• Editorial and Peer Review
• Issues archive
• Authors
• Articles
  • By alphabet
  • By category
• Blogs and comments

The journal is included into The list of leading scientific periodicals.

The journal is included into VINITI database and is registered in Electronic scientific library.

The journal is indexed by SCOPUS, Ulrich's International Periodicals Directory.

EBSCO

https://doi.org/10.14300/mnnc.2021.16071

Immunophenotype characteristics of glycogen-rich clear cell breast carcinoma

[Original research] [Morphology]
Grigory Demyashkin; Andrey Ryzhov; Alexey Sidorin; Margarita Gevandova; Vladimir Ivanovich Shchekin; Anna Kolyada;

Glycogen-rich clear cell carcinoma (GRCC) is a rare variant of invasive ductal carcinoma (about 1–3 %). Cases diagnosed with GRCC (n=9) were discovered in archival materials of breast cancer (n=2240, from 2010 to 2017). The existence of the PASpositive cancer cells, as well as a moderate degree of cell proliferation of Ki-67 (26,3±0,1 %) against the background of p63 decrease (7,1±0,1 %) and an increase of HER2/neu expression (82,2±0,5 %), in the absence of ER and PGR labeling was found by using a complex of morphological and immunohistochemical methods. Based on the data obtained, it can be concluded that this tumor has a dismal prognosis.

Download

References:
1. Lakhani S. R., Ellis I. O., Schnitt S. J., Tan P. H., van de Vijver M. J. World Health Organization Classification of Tumours of the Breast, 4th Edition, Vol. 4. Lyon: IARC Press, 2012.
2. Hull M. T., Priest J. B., Broadie T. A., Ransburg R. C., McCarthy L. J. Glycogen-rich clear cell carcinoma of the breast: a light and electron microscopic study. Cancer. 1981;48:2003-2009.
3. Muna M. B., Enaam M. J., Hadeel H. A., Anmar F. S., Ahmed O. A. [et al.]. Glycogen Rich Clear Cell Carcinoma (GRCC) of the breast may not have a poor prognosis. Int. J. Surg. Case Rep. 2017;33:92-96.
https://doi.org/10.1016/j.ijscr.2017.02.044
4. Xiangmin Ma, Yunwei Han, Yu Fan, Xuchen Cao, Xin Wang. Clinicopathologic Characteristics and Prognosis of Glycogen-Rich Clear Cell Carcinoma of the Breast. Breast J. 2014;20(2):166-173.
https://doi.org/10.1111/tbj.12231
5. Solanki M. H., Derylo A. F., Jorns J. M. Invasive Mammary Carcinoma With Mixed Invasive Papillary and Glycogen Rich Clear Cell Features. Int. J. Surg. Pathol. 2018.
https://doi.org/10.1177/1066896918765651
6. Demyashkin G. A., Pastuhova D. A., Serdyuk I. A., Sidorin A. V. Mucinoznaya karcinoma molochnoj zhelezy: immunofenotipicheskaya harakteristika. Krymskij zhurnal ehksperimental’noj i klinicheskoj mediciny. – Crimean Journal of Experimental and Clinical Medicine. 2017;7(2):40-45. (In Russ.).
7. Kuroda H., Sakamoto G., Ohnisi K., Itoyama S. Clinical and Pathological Features of Glycogen-Rich Clear Cell Carcinoma of the Breast. Breast Cancer. 2005;12(3):189-195.
https://doi.org/10.2325/jbcs.12.189
8. Ovanez C., Crawford J., Asarian A., Xiao P. Invasive ductal carcinoma of the breast with clear cell and pseudo-lacting changes. J. Surg. Case Rep. 2014;7(3).
https://doi.org/10.1093/jscr/rju063

Keywords: breast carcinoma, glycogen-rich clear cell carcinoma, Ki-67, p53, HER2/neu, ER, PGR