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https://doi.org/10.14300/mnnc.2021.16046

Features of highly specific factors of endothelial dysfunction and indicators of the hemostatic system and lipid metabolism in rats under various experimental conditions

[Experimental medicine]
Ludmila Tsaturian; Elena Melikbekian; Tamara Dzhandarova; Lyudmila Olegovna Knyazhetskaya; Vladimir Baturin; Evgeny Shchetinin;

This study involved an investigation of lipidogram and coagulogram parameters with assessment of highly specific markers of endothelial dysfunction in 44 Wistar rats under various experimental conditions. Significant intersystem relationships were revealed between the content of circulating endothelial cells and the activated partial thromboplastin time, prothrombin time, platelet count, fractions of atherogenic lipoproteins, and atherogenic coefficient in animal models of hypercoagulation, dyslipidemia, and mild stress.

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Keywords: endothelial dysfunction, lipid profile, coagulogram parameters, mild stress, experimental animals