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https://doi.org/10.14300/mnnc.2021.16045

Practical application of efficiency estimation of nanosized zinc oxide in the therapy of burn wounds

[Experimental medicine]
Karine Elbekyan; Andrey Vladimirovich Blinov; Anastasiya Aleksandrovna Blinova; Natalya Viktorovna Fedota; Vladimir Alexandrovich Orobets; Alexander Vladimirovich Serov;

The efficiency assessment of nanosized zinc oxide (ZnO) as a component of a high-potency wound-healing ointment composition was performed. The ointment consisted of a hydrophilic methylcellulose base and 5 wt. % ZnO nanoparticles as an active substance. Nanosized ZnO was obtained by the sol-gel method. Commercial zinc ointment was used as a comparison sample. Planimetric studies were conducted on the effectiveness of burn wound healing in white Wistar rats. Three cases were considered: wounds were treated using a pharmaceutical zinc ointment or the ointment with ZnO nanoparticles, or received no treatment. Histological studies of the effectiveness of wound healing on treatment with the ointment containing ZnO nanoparticles were also performed. The ointment with the nanosized ZnO-based composition based had a pronounced regenerative effect on burn wounds. Its effect was greater than that of the existing analog – pharmaceutical zinc ointment.

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References:
1. Mishra P. K., Mishra H., Ekielski A., Talegaonkar S., Vaidya B. Zinc oxide nanoparticles: A promising nanomaterial for biomedical applications. Drug Discov. Today. 2017:6446. https://doi.org/10.1016/j.drudis.2017.08.006
2. Sardella D., Gatt R., Valdramidis V. P. Physiological effects and mode of action of ZnO nanoparticles against postharvest fungal contaminants. Food Res. Int. 2017;101:274-279. https://doi.org/10.1016/j.foodres.2017.08.019
3. Gutha Y., Pathak J. L., Zhang W., Zhang Y., Jiao X. Antibacterial and wound healing properties of chitosan/poly(vinyl alcohol)/zinc oxide beads (CS/PVA/ZnO). Int. J. Biol. Macromol. 2017;103:234–241. https://doi.org/10.1016/j.ijbiomac.2017.05.020
4. Bae Y. S., Hill N. D., Bibi Y., Dreiher J., Cohen A. D. Innovative uses for zinc in dermatology. Dermatol. Clin. 2010;28:587-597. https://doi.org/10.1016/j.det.2010.03.006
5. Agarwal H., Kumar S. V., Rajeshkumar S. A review on green synthesis of zinc oxide nanoparticles – An ecofriendly approach. Resour. Technol. 2017;3(4):406-413. https://doi.org/10.1016/j.reffit.2017.03.002
6. Sonia S., Linda J. K. H., Ruckmani K., Sivakumar M. Antimicrobial and antioxidant potentials of biosynthesized colloidal zinc oxide nanoparticles for a fortified cold cream formulation: A potent nanocosmeceutical application. Materials Science and Engineering. 2017;79:581-589. https://doi.org/10.1016/j.msec.2017.05.059
7. Rakhshaei R., Namazi H. A potential bioactive wound dressing based on carboxymethyl cellulose/ZnO impregnated MCM-41 nanocomposite hydrogel. Mater. Sci. Eng. C. 2017;73:456-464. https://doi.org/10.1016/j.msec.2016.12.097
8. Raguvaran R., Manuja B. K., Chopra M., Thakur R., Anand T. [et al.] Sodium alginate and gum acacia hydrogels of ZnO nanoparticles show wound healing effect on fibroblast cells. Int. J. Biol. Macromol. 2017;96:185-191. https://doi.org/10.1016/j.ijbiomac.2016.12.009
9. Olbert M., Gdula-Argasinska J., Nowak G., Librowski T. Beneficial effect of nanoparticles over standard form of zinc oxide in enhancing the anti-inflammatory activity of ketoprofen in rats. Pharmacol. Reports. 2017;69:679-682. https://doi.org/10.1016/j.pharep.2017.02.004
10. Nagajyothi P. C., Cha S. J., Yang I. J., Sreekanth T. V. M., Kim K. J. [et al.] Antioxidant and anti-inflammatory activities of zinc oxide nanoparticles synthesized using Polygala tenuifolia root extract. J. Photochem. Photobiol. B. Biol. 2015;146:10-17. https://doi.org/10.1016/j.jphotobiol.2015.02.008
11. Mirzaei H., Darroudi M. Zinc oxide nanoparticles: Biological synthesis and biomedical applications. Ceram. Int. 2017;43:907-914. https://doi.org/10.1016/j.ceramint.2016.10.051
12. Lu Z., Gao J., He Q., Wu J., Liang D. [et al.] Enhanced antibacterial and wound healing activities of microporous chitosan-Ag/ZnO composite dressing. Carbohydr. Polym. 2017;156:460-469. https://doi.org/10.1016/j.carbpol.2016.09.051
13. Khalid A., Khan R., Ul-Islam M., Khan T., Wahid F. Bacterial cellulose-zinc oxide nanocomposites as a novel dressing system for burn wounds. Carbohydr. Polym. 2017;164:214-221. https://doi.org/10.1016/j.carbpol.2017.01.061
14. Jarrousse V., Castex-Rizzi N., Khammari A., Charveron M., Drеno B. Zinc salts inhibit in vitro Toll-like receptor 2 surface expression by keratinocytes, Eur. J. Dermatology. 2007;17:492-496. https://doi.org/10.1684/ejd.2007.0263
15. Lansdown A. B. G., Mirastschijski U., Stubbs N., Scanlon E., Аgren M. S. Zinc in wound healing: Theoretical, experimental, and clinical aspects. Wound Repair Regen. 2007;15:2-16. https://doi.org/10.1111/j.1524-475X.2006.00179.x
16. Tarakanov V. A., Minaev S. V., Kolesnikov E. G., Korotkov K. G., Abushkevich V. G. [et al.] Topical diagnosis of the boundaries of necrotic segment of the small intestine in the high frequency electromagnetic fields. Medical News of North Caucasus. 2019;14(2):308-311. https://doi.org/10.14300/mnnc.2019.14074
17. Soo C., Shaw W. W., Zhang X., Longaker M. T., Howard E. W., Ting K. Differential expression of matrix metalloproteinases and their tissue-derived inhibitors in cutaneous wound repair. Plast. Reconstr. Surg. 2000;105:638-647.
18. Ravanti L., Kаhаri V. M. Matrix metalloproteinases in wound repair (review). Int. J. Mol. Med. 2000;6:391-407. https://doi.org/10.3892/ijmm.6.4.391
19. Alpaslan G., Nakajima T., Takano Y. Extracellular alkaline phosphatase activity as a possible marker for wound healing: a preliminary report. J. Oral Maxillofac. Surg. 1997;55:53-56.
20. Sоderberg T., Hallmans G., Аgren M., Tengrup I., Banck G. The effects of an occlusive zinc medicated dressing on the bacterial flora in excised wounds in the rat. Infection. 1989;17:81-85. https://doi.org/10.1007/BF01646881
21. Pourrahimi A. M., Liu D., Pallon L. K. H., Andersson R. L., Martínez A. [et al.] Water-based synthesis and cleaning methods for high purity ZnO nanoparticles – comparing acetate, chloride, sulphate and nitrate zinc salt precursors. RSC Adv. 2014;4:35568-35577. https://doi.org/10.1039/C4RA06651K
22. Gladkova E. V., Babushkina I. V., Mamonova I. A., Matveeva O. V., Belova S. V. Effect of a complex preparation on regeneration of the experimental soft tissue wound. World J. Med. Sci. 2013;8:226-230. https://doi.org/10.5829/idosi.wjms.2013.8.3.7364
23. Minaev S. V., Grigorova A. N., Vladimirova O. V., Timofeev S. I., Sirak A. G. [et al.] Influence of connective tissue differentiation on scar tissue formation in children. Khirurgiya. 2021;(5):72-77. https://doi.org/10.17116/hirurgia202105172
24. Dodge R. Histological Techniques. Br. J. Cancer. 1977. https://doi.org/10.1016/j.etp.2009.02.087
25. Munro B. H. Manual of Histologic Staining Methods of the Armed Forces Institute of Pathology. Pathology. 1971. https://doi.org/10.1016/S0031-3025(16)39410-7
26. Abdelrahman T., Newton H. Wound dressings: Principles and practice. Surgery. 2011;29:491-495. https://doi.org/10.1016/j.mpsur.2011.06.007
27. Singh S., Young A., McNaught C. E. The physiology of wound healing. Surg. 2017;35:473-477. https://doi.org/10.1016/j.mpsur.2017.06.004
28. Broughton G., Janis J. E., Attinger C. E. Wound Healing: An Overview. Plast. Reconstr. Surg. 2006;117:1e-S-32e-S. https://doi.org/10.1097/01.prs.0000222562.60260.f9
29. Blinov A. V., Siddiqui S. A., Nagdalian A. A., Blinova A. A., Gvozdenko A. A. [et al.] Investigation of the influence of Zinc-containing compounds on the components of the colloidal phase of milk. Arab. J. Chem. 2021;14(7):103229 https://doi.org/10.1016/j.arabjc.2021.103229

Keywords: zinc oxide nanoparticles, ointment, wound healing, burn injuries, regenerative effect