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https://doi.org/10.14300/mnnc.2021.16043

The role of dysmetabolic mechanisms in the development of neurodegenerative processes in an experimental metabolic-cognitive syndrome model

[Experimental medicine]
Vitalina Igorevna Petrenko; Alina Alekseevna Shevandova; Anatoly Vladimirovich Kubyshkin; Irina Ivanovna Fomochkina; Yulianna Ivanovna Shramko; Tatiana Pavlovna Makalish; Yuri Alekseevich Ogay; Denis Rashidovich Khusainov;

This article describes the role of dysmetabolic mechanisms in the development of neurodegenerative processes in an experimental animal model of metabolic-cognitive syndrome. Cognitive decline and neurodegenerative changes in experimental animals were revealed in the form of decreased cortical thickness in the temporal and parietal lobes of the brain. Administration of polyphenol preparations prevented morphological and functional changes in animals. Neuroprotection in individuals with metabolic syndrome can be individualized using drugs with different polyphenol compositions.

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Keywords: neurodegeneration, metabolic syndrome, cognitive impairment, polyphenols