Site search
Correspondence address
310 Mira Street, Stavropol, Russia, 355017
Tel
+7 865 2352511, +7 865 2353229.
E-mail
medvestnik@stgmu.ru
The journal is included into The list of leading scientific periodicals.
The journal is included into VINITI database and is registered in Electronic scientific library.
The journal is indexed by SCOPUS, Ulrich's International Periodicals Directory.
[Experimental medicine]
Azamat Kade; Artem Ivanovich Trofimenko; Sergey Borisovich Bogdanov; Yulia Valentinovna Galushko; Sabina Muratovna Zench;
The influence of D-asparagine on the engraftment of a biopolymer scaffold, the main components of which were sodium alginate and gelatin, for replacing skin defects after necrectomy of burn wounds was investigated in an experimental rat model. The results of morphometric and fractal analyses of histological micro-preparations showed that the inclusion of D-asparagine in the composition of the scaffold had a positive effect on its engraftment and remodeling on day 30 after implantation. The study showed that the proposed scaffold is a promising material for replacing the skin in burn wounds.
References:
1. Kogan S., Halsey J., Agag R. L. Biologics in Acute Burn Injury. Annals of Plastic Surgery. 2019;83(1):26-33. https://doi.org/10.1097/SAP.0000000000001915
2. Lo C. H., Chong E., Akbarzadeh S., Brown W. A., Cleland H. A systematic review: Current trends and take rates of cultured epithelial autografts in the treatment of patients with burn injuries. Wound Repair and Regeneration. 2019;27(6):693-701. https://doi.org/10.1111/wrr.12748
3. Nielson C. B., Duethman N. C., Howard J. M., Moncure M., Wood J. G. Burns: Pathophysiology of Systemic Complications and Current Management. Journal Burn Care & Research. 2017;38(1):e469-e481. https://doi.org/10.1097/BCR.0000000000000355
4. Afjoul H., Shamloo A., Kamali A. Freeze-gelled alginate/gelatin scaffolds for wound healing applications: An in vitro, in vivo study. Materials Science and Engineering. 2020;113:110957. https://doi.org/10.1016/j.msec.2020.110957
5. Jin S., Xia X., Huang J., Yuan C., Zuo Y. [et al.] Recent Advances in PLGA-based Biomaterials for Bone Tissue Regeneration. Acta Biomaterialia. 2021:S1742-7061(21) 00224-5. https://doi.org/10.1016/j.actbio.2021.03.067
6. Sergeeva Yu. А., Trofimenko А. I., Fedorenko Т. V., Gilevich I. V., Kolomiyceva Е. А., Kade А. H. Influence of D-asparagine on the proliferative activity of human dermal fibroblasts. Medical News of North Caucasus. 2020;15(3):360-363. https://doi.org/10.14300/mnnc.2020.15085
7. Genchi G. An overview on D-amino acids. Amino Acids. 2017;49(9):1521-1533. https://doi.org/10.1007/s00726-017-2459-5
8. Du S., Wang Y., Alatrash N., Weatherly C. A., Roy D. [et al.] Altered profiles and metabolism of l-and d-amino acids in cultured human breast cancer cells vs non-tumorigenic human breast epithelial cells. Journal of Pharmaceutical and Biomedical Analysis. 2019;164:421-429. https://doi.org/10.1016/j.jpba.2018.10.047
9. Cai E. Z., Ang C. H., Raju A., Tan K. B., Hing E. C. H. [et al.] Creation of consistent burn wounds: a rat model. Archives of Plastic Surgery. 2014;41(4):317-324. https://doi.org/10.5999/aps.2014.41.4.317
10. Lopes R., Betrouni N. Fractal and multifractal analysis: a review. Medical Image Analysis. 2009;13(4):634-49. https://doi.org/10.1016/j.media.2009.05.003
11. Frisch K. E., Duenwald-Kuehl S. E., Kobayashi H., Chamberlain C. S., Lakes R. S. [et al.] Quantification of collagen organization using fractal dimensions and Fourier transforms. Acta histochemica. 2012;114(2):140-144. https://doi.org/10.1016/j.acthis.2011.03.010
Keywords: D-asparagine, biopolymer scaffold, skin, burn, fractal analysis