• Main page
• About the journal
• Editorial board
• Subscription
• Information for contributors
• Editorial and Peer Review
• Issues archive
• Authors
• Articles
  • By alphabet
  • By category
• Blogs and comments

The journal is included into The list of leading scientific periodicals.

The journal is included into VINITI database and is registered in Electronic scientific library.

The journal is indexed by SCOPUS, Ulrich's International Periodicals Directory.

EBSCO

https://doi.org/10.14300/mnnc.2021.16035

Estimation of blood antimicrobial peptide levels in women of reproductive age with pelvic inflammatory disease before and after antibiotic therapy

[Clinical Pharmacology]
Vladimir Baturin; Roberta Boshyan;

Blood α-defensin-1 (DEFa1) and β-defensin-1 (DEFb1) levels in 56 women of reproductive age with pelvic inflammatory disease were evaluated before and after antibiotic therapy. DEFa1 levels were decreased by 20 % after tetracycline monohydrate therapy (n=22), by 15.6 % after levofloxacin therapy (n=18), and by 25 % after josamycin therapy (n=16) compared with before therapy. DEFb1 levels were increased by 17 % after tetracycline monohydrate therapy, by 45 % after josamycin therapy, and by 80 % after levofloxacin therapy compared with before therapy. Our study shows that blood antimicrobial peptide levels in women with pelvic inflammatory disease are different and depend on the antibacterial drug used.

Download

References:
1. Kozlov R. S. Antibiotic resistance as a major concern modern healthcare. Bulletin of Roszdravnadzor. 2017;(4):28-33.
2. Tetelyutina F. K., Kopieva O. V. Possibilities of immune correction in chronic inflammatory diseases of pelvic organs. Modern problems of science and education. 2015;1(1):1370-1371. Available at: https://www.scienceeducation.ru/ru/article/view?id=18247
3. Sharma H., Tal R., Clark N. A. Microbiota and pelvic inflammatory disease. Seminars in Reproductive Medicine. 2014;32(1):43-49. https://doi.org/10.1055/s-0033-1361822
4. Ali A.S., Townes C. L., Hall J., Pickard R. S. Maintaining a sterile urinary tract: the role of antimicrobial peptides. J. Urol. 2009;182:21-28. https://doi.org/10.1016/j.juro.2009.02.124
5. Zasloff M. Antimicrobial peptides, innate immunity, and the normally sterile urinary tract. J. Am. Soc. Nephrol. 2007;18:2810-2816. https://doi.org/10.1681/ASN.2007050611
6. Abaturov A. E., Gerasimenko O. N., Vysochina I. L., Zavgorodnyaya, N. Yu. Defensins and defensin-dependent diseases. О.: VMV. 2011:264.
7. Rohrl J., Yang D., Oppenheim J. J., Hehlgans T. Human β-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2. J. Immunol. 2010;184:6688-6694. https://doi.org/10.4049/jimmunol.0903984
8. Sakamoto N., Mukae H., Fujii T., Ishii H., Yoshioka S. [et al.] Differential effects of alpha- and beta-defensin on cytokine production by cultured human bronchial epithelial cells. Am. J. Physiol. Lung. Cell. Mol. Physiol. 2005;288(3):508-513. https://doi.org/10.1152/ajplung.00076.2004
9. Rathinakumar R., Walkenhorst W. F., Wimley W. C. Broadspectrum antimicrobial peptides by rational combinatorial design and high-throughput screening: the importance of interfacial activity. J. Am. Chem. Soc. 2009;131:7609-7617. https://doi.org/10.1021/ja8093247
10. Zharkova M. S., Orlov D. S., Kokryakov V. N., Shamova O. V. Mammalian antimicrobial peptides: classification, biological role, practical application prospects (review article). Vestnik Sankt-Peterburgskogo Universiteta. Seriya 3. Biologiya. 2014;1:98-114.
11. Yeaman M. R., Yount N. Y. Mechanisms of antimicrobial peptide action and resistance. Pharmacol. Rev. 2003;55:27-55. https://doi.org/10.1124/pr.55.1.2
12. Brogden K. A. Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Nat. Rev. Microbiol. 2005;3(3):238-250. https://doi.org/10.3389/fnins.2017.00073
13. Splith K., Neundorf I. Antimicrobial peptides with cellpenetrating peptide properties and vice versa. Eur. Biophys. J. 2011;40:387-397. https://doi.org/10.1007/s00249-011-0682-7
14. Boshyan R. O., Baturin V. A. Estimation of the level of anti-microbial peptides in women of reproductive age with inflammatory diseases of the pelvic organs under the conditions of outpatient department. Medical News of North Caucasus. 2019;14(2):322-324. https://doi.org/10.14300/mnnc.2019.14078
15. Baturin V. A., Boshyan R. O. Study of the microbiota of the urogenital tract women of a reproductive age with inflammatory diseases of small pelvic organs under the conditions of out-patient department. Medical News of North Caucasus. 2018;13(2):415-416. https://doi.org/10.14300/mnnc.2018.13065
16. 2018 European (IUSTI/WHO) Guideline on the Management of Vaginal Discharge. https://doi.org/10.1177/0956462418785451

Keywords: antimicrobial peptide, α-defensin-1, β-defensin-1, pelvic inflammatory disease, antibiotic therapy, levofloxacin, josamycin, tetracycline monohydrate