• Main page
• About the journal
• Editorial board
• Subscription
• Information for contributors
• Editorial and Peer Review
• Issues archive
• Authors
• Articles
  • By alphabet
  • By category
• Blogs and comments

The journal is included into The list of leading scientific periodicals.

The journal is included into VINITI database and is registered in Electronic scientific library.

The journal is indexed by SCOPUS, Ulrich's International Periodicals Directory.

EBSCO

https://doi.org/10.14300/mnnc.2021.16007

Evaluation of IgG-dependent humoral and cellular immunity in persons after Covid-19 and in healthy volunteers

[Infectious diseases]
Vladimir Baturin; Ekaterina Vladimirovna Grudina; Natalia Dmitrievna Zagrebailova; Mikhail Baturin; Arevik Arkadyevna Fil; Vasiliy Fisher; Vladimirovna Kostrovskaya Marina; Mariya Baturina;

43 individuals (medical workers) were examined, 15 of them suffered from COVID-19; 7 persons had negative PCR tests, however, there were signs of a respiratory infection in the anamnesis; 21 participants denied having had COVID-19 and any respiratory infections in the past year. The serum level of neutralizing IgG to S-trimer Protein SARS-Cov-2 was determined. The number of antigen-recognizing receptors of B lymphocytes represented by membrane IgG to S-trimer Protein SARSCov-2 was also evaluated. It was found that in some of the subjects who consider themselves not sick, antibodies and antigen-recognizing receptors of B-lymphocytes are not detected. However, a significant proportion of «healthy» individuals (67 %) were found to have elevated levels of serum antibodies and a high number of antigen-recognizing receptors. Persons who recovered from COVID-19 had elevated levels of serum IgG antibodies and high levels of antigen-recognizing receptors of B-lymphocytes in peripheral blood. However, in patients with a more severe course of infection who were prescribed glucocorticosteroids during the treatment, the serum IgG and lymphocyte receptor levels were lower. Individuals who noted respiratory infection of varying severity during the epidemic period, but not confirmed by PCR for COVID-19 and did not receive glucocorticosteroids, there were high levels of serum neutralizing IgG antibodies and a high content of antigenrecognizing receptors of peripheral blood B-lymphocytes, represented by membrane IgG to S-trimer Protein SARS-Cov-2.

Download

References:
1. Dalan R., Boehm B. O., Borstein S. R., Beuschlein F.,El-Armouche A. [et al.] The ACE-2 in COVID-19: Foe or Friend? Hormon. Metab. Res. 2020;2(5):257-263. https://doi.org/10.1055/a-1155-0501
2. Wu Y., Ho W., Huang Y., Jin D. Y., Li S. [et al.]. SARSCoV-2 is an appropriate name for the new oronavirus.Lancet. 2020;395(10228):949-950. https://doi.org/10.1016/S0140-6736(20)30557-2
3. Zhu N., Zhang D., Wang W., Li X., Yang B. [et al.]. A novel coronavirus from patients with pneumonia in China,2019. New Engl. J. Med. 2020;382(8):727-733. https://doi.org/10.1056/NEJMoa2001017
4. Namazova-Baranova L. S., Baranov A. A. COVID-19: what pediatricians learned about the features of the immune response to a new coronavirus infection during the year of fighting it. Pediatria. Zhurnal im. G. N. Speranskogo. – Pediatrics. The journal named after G. N. Speransky. 2020;99(6):32-51. (In Russ). https://doi.org/10.24110/0031-403X-2020-99-6-32-51
5. Zhang Y., Wang S., Wu Y., Hou W., Yuan L. [et al.]. Virus-Free and Live-Cell Visualizing SARS-CoV-2 Cell Entry for Studies of Neutralizing Antibodies and Compound Inhibitors. Small Methods. 2021;5(2):2001031. https://doi.org/10.1002/smtd.202001031
6. Lumley S. F., O’Donnell D., Stoesser N. E., Matthews P. C., Howarth A. [et al.]. Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers. New Engl. J. Med. 2021;384(6):533-540. https://doi.org/10.1056/NEJMoa2034545

Keywords: Covid-19, S-trimer Protein SARS-CoV-2, IgG immunoglobulins, antigen-recognition receptors of B-lymphocytes