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Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
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The spectrum of antibacterial activity of defensins against gram-positive and gram-negative bacterial strains isolated from hospitalized patients

[Abstracts]
Albert Bolatchiev;

The antimicrobial activity of antimicrobial peptides (defensins HNP-1, hBD-1, hBD-3) against clinical strains of grampositive and gram-negative bacteria was studied. All studied defensins demonstrated antimicrobial effect. HNP-1 showed the best activity against gram-positive strains. hBD-3 had the lowest values of the minimum inhibitory concentration compared to the rest of the studied defensins.

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References:
1. Prestinaci F., Pezzotti P., Pantosti A. Antimicrobial resistance: a global multifaceted phenomenon. Pathognes and Global Health. 2015;109(7):309-318. https://doi.org/10.1179/2047773215Y.0000000030
2. Pachón-Ibáñez M. E., Smani Y., Pachón J., Sánchez-Céspedes J. Perspectives for clinical use of engineered human host defense antimicrobial peptides. FEMS Microbiology Reviews. 2017;41(3):323-342. https://doi.org/10.1093/femsre/fux012
3. Bolatchiev A., Baturin V., Bazikov I., Maltsev A., Kunitsina E. Effect of antimicrobial peptides HNP-1 and hBD-1 on Staphylococcus aureus strains in vitro and in vivo.Fundamental and Clinical Pharmacology. 2020;34(1):102-108. https://doi.org/10.1111/fcp.12499
4. Zharkova M. S., Orlov D. S., Golubeva O. Y., Chakchir O. B., Eliseev I. E. [et al.]. Application of antimicrobial peptides of the innate immune system in combination with conventional antibiotics-a novel way to combat antibiotic resistance? Frontiers in Cellular and Infection Microbiology. 2019;9(APR):128. https://doi.org/10.3389/fcimb.2019.00128

Keywords: antimicrobial peptides, defensins, antibiotic resistance, HNP-1, hBD-1, hBD-3


Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy