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https://doi.org/10.14300/mnnc.2020.15132

Features of cytoarchitectonics of the cerebellar cortex during aging on the example of inferior semilunar lobule

[Morphology]
Anatoly Alexandrovich Balandin; Lev Mikhailovich Zheleznov; Irina Anatolyevna Balandina; Vladimir Aleksandrovich Balandin; Ekaterina Lahaina Kobaidze;

A study of the cerebellum was carried out on 55 corpses of men and 58 corpses of women aged 24–35 years and 75–88 years, respectively, without diseases and injuries of the central and peripheral nervous systems in the anamnesis, as well as without alcohol/drug addiction. All examined were right-handed. We used histological, immunohistochemical, and micrometric methods. The thickness of the molecular and granular layers of the cerebellar cortex in the lower semilunar lobule in both hemispheres was determined. For immunohistochemical study, a panel of antibodies to glial fibrillar acidic protein (GFAP) and neurospecific enolase (NSE) was used. Comparative analysis of the data in the age aspect showed a statistically significant decrease in the parameters of the thickness of the molecular layer in elderly. The granular layer has a less pronounced dynamics of thinning with age, however, there is a tendency for its indicators to decrease from young to old age. Immunohistochemical study revealed a significant growth of GFAP-positive astroglia in the cerebellar cortex closer in elderly and a decrease in the number of Purkinje cells immunopositive to NSE.

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Keywords: cerebellar cortex, GFAP, NSE, astroglia, molecular layer, granular layer, lower semilunar lobule, Purkinje cells, aging