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https://doi.org/10.14300/mnnc.2020.15126

Effectiveness of antioxidant correction in patients with chronic inflammatory uterine disease and metabolic syndrome

[Obstetrios and gynecology]
Tatyana Georgievna Melkonyants; Ilya Bykov; Konstantin Popov; Yulia Vitalievna Grushevskaya; Aleksandr Storozhuk;

The paper presents indicators of oxidative homeostasis in women with chronic inflammatory uterine disease, isolated or combined with metabolic syndrome, before and after standard therapy with the inclusion of ubiquinone, lipoic acid, retinol and tocopherol. It was found that the course of the underlying disease against the background of metabolic syndrome is accompanied by pronounced violations of oxidative homeostasis, which persist after standard therapy. The addition of antioxidants increased the total antioxidant activity of blood plasma by 86 %, reduced the level of TBA-active products by 1.9–2.1 times, with an increase in the concentration of metabolites of thiol homeostasis to normal values. Normalization of oxidative homeostasis in the future can not only improve the course of gynecological disease, reduce the frequency and severity of exacerbations, but also slow down the progression of metabolic syndrome.

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Keywords: chronic inflammatory uterine disease, endometritis, metabolic syndrome, metabolic therapy, antioxidants, oxidative stress