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https://doi.org/10.14300/mnnc.2020.15118

Evaluation of vitamin status of patients with morbid obesity by the complex of optimal sufficiency criteria

[Clinical Pharmacology] [Pharmacology]
Oksana A. Vrzhesinskaya; Nina Alekseevna Beketova; Olga Vasilyevna Kosheleva; Vera Mitrofanovna Kodentsova; Haider Hasanovic Sharafetdinov;

Simultaneously optimized concentrations of vitamin C, tocopherols, carotenoids and their ratios in blood plasma have a protective effect on many alimentary diseases. The aim of the work was to assess vitamin status of patients with morbid obesity from the standpoint of adequacy but also using the optimality criteria simultaneously for several indicators. An observational study of the provision of vitamins was carried out in 81 patients (21 men, 60 women) 20–75 years old (35 patients with obesity, 27 with cardiovascular diseases (CVD), 19 with type 2 diabetes mellitus (T2DM)) by means of serum level of β-carotene, α-and γ-tocopherols, ascorbic acid and their ratio between each other and cholesterol-adjusted α-tocopherol. The suboptimal level of β-carotene, vitamin C and vitamin C/E ratio among patients with T2DM was statistically significantly more frequent (63.2 %, p <0.5) than among patients with obesity (20.0 %) and CVD (22.2 %). In terms of coincidence of the frequency of several parameters of suboptimal sufficiency, patients with T2DM turned out to be worse supplied with antioxidant vitamins. Only in two patients with obesity and two patients with CVD, all the indicators of vitamin status were at the optimum level. Most patients need to increase the intake of β-carotene, vitamins C and E, but in a different ratio, that requires additional research on the selection of combinations and doses of antioxidant vitamins.

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Keywords: antioxidants, vitamins, optimal concentration, serum, cholesterol-adjusted α-tocopherol, obesity