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of the North Caucasus
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Series ПИ #ФС 77-26521.
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ISSN 2073-8137

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Molecular allergy diagnostics and improving allergen-specific immunotherapy in the cases of sensitization to weed pollen

Lyudmila Valentinovna Dushina; Lyudmila Barycheva; Milana Minasyan;

The results of a study of data from 60 patients with allergic rhinitis, sensitized to weed pollen, are presented. According to the results of skin tests, 20 % showed monosensitization to ragweed, 20 % – oligosensitization to ragweed and wormwood, 60 % – polysensitization to weeds, timothy grass, birch. Specific antibodies to the major ragweed allergen (IgE nAmb a1) has been detected in 81.7 % of patients, wormwood (IgE nArt v1) – in 26.7 %, timothy grass (IgE rPhl p1.5) – in 10.0 %, birch (IgE Bet v1) – in 6.7 %. Molecular component-separated allergy diagnostics may result in changed allergen-specific immunotherapy program in 43.3 % of patients sensitized to weed pollen.


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Keywords: pollen allergy, weeds, molecular diagnostics, allergen-specific immunotherapy

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy