Site search
Correspondence address
310 Mira Street, Stavropol, Russia, 355017
Tel
+7 865 2352511, +7 865 2353229.
E-mail
medvestnik@stgmu.ru
The journal is included into The list of leading scientific periodicals.
The journal is included into VINITI database and is registered in Electronic scientific library.
The journal is indexed by SCOPUS, Ulrich's International Periodicals Directory.
[Experimental medicine]
Svetlana Alexandrovna Demyanenko; Andrey Leonidovich Morozov; Marina Morozova; Dmitry Shabliy; Anastasia Eduardovna Denga;
The aim of this study was to determine the effect of orthodontic tooth relocation on the periodontal condition in rats with experimental diabetes mellitus and to determine the possibility of preventing pathological changes using antidysbiotic agents. In experiments on white Wistar rats, the gums and periodontal bone tissue were isolated, and blood serum was also obtained. The level of biochemical markers of inflammation was determined in the gingival homogenate, and the activity of alkaline and acid phosphatases, the activity of elastase, as well as the content of calcium and protein, were determined in the homogenate of the periodontal bone tissue. The research results indicate the development of systemic inflammation, activation of lipid peroxidation, inflammation and an increase in contamination of opportunistic microbiota on the gums, the development of dysbiosis against the background of a decrease in antimicrobial protection in the oral cavity. The results give grounds to recommend the use of the investigated antidysbiotics before orthodontic tooth relocation in patients with diabetes mellitus.
References:
1. Mohamed N. A., Ahmed O. M., Hozayen W. G., Ahmed M. A. Ameliorative effects of bee pollen and date palm pollen on the glycemic state and male sexual dysfunctions in streptozotocin-Induced diabetic wistar rats. Biomed Pharmacother. 2018;97:9-18. https://doi.org/10.1016/j.biopha.2017.10.117
2. Gupta A., Aggarwal V., Mehta N., Abraham D., Singh A. Diabetes mellitus and the healing of periapical lesions in root filled teeth: a systematic review and meta-analysis. International Endodontic Journal. 2020. https://doi.org/10.1111/iej.13366
3. Lambert-Obry V., Lafrance J. P., Savoie M., Henri S., Lachaine J. Review of real-world evidence studies in type 2 diabetes mellitus: Lack of good practices. International Journal of Technology Assessment in Health Care. 2020;24:1-8. https://doi.org/10.1017/S0266462320000392
4. Wu C. Z., Yuan Y. H., Liu H. H., Li S. S., Zhang B. W. [et al.] Epidemiologic relationship between periodontitis and type 2 diabetes mellitus. BMC Oral Health. 2020;20(1):204. https://doi.org/10.1186/s12903-020-01180-w
5. Grimm W. D., Shchetinin E. V., Bobrishev D. V., Sirak S. V. Quantifying analysis of advanced glycosylation end products (AGES) expression in periodontitis patients with diabetes type II. Medical News of North Caucasus. 2015;10(2):178-183. https://doi.org/10.14300/mnnc.2015.10042
6. Al-Megrin W. A., El-Khadragy M. F., Hussein M. H., Mahgoub S., Abdel-Mohsen D. M. [et al.]. Green Coffea arabica Extract Ameliorates Testicular Injury in High-Fat Diet/Streptozotocin-Induced Diabetes in Rats. Journal of Diabetes Research. 2020;2020:6762709. https://doi.org/10.1155/2020/6762709
7. Aghaei Z. S. M., Dehghan T. M., Talebi M., Vahidi M. M. Y. Molecular biomarkers in diabetes mellitus. Medical Journal of the Islamic Republic of Iran. 2020;34:28. https://doi.org/10.34171/mjiri.34.28
8. Klenovskaya S. V., Schneider S. A., Maslov A. V. Features of changes in the microbiota of the oral cavity in patients with diabetes. Vestnik stomatologii. –Dentistry Bulletin. 2019;(2):29-33. (In Russ.).
9. Aw W., Fukuda S. Understanding the Role of the Gut Ecosystem in Diabetes Mellitus. Journal of Diabetes Investigation. 2018;9(1):5-12. https://doi.org/10.1111/j
Keywords: rats, experiment, diabetes, orthodontics