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of the North Caucasus
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ISSN 2073-8137

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Effect of antidisbiotic drugs on periodontal tissues of rats with diabetes mellitus after orthodontic tooth relocation

[Experimental medicine]
Svetlana Alexandrovna Demyanenko; Andrey Leonidovich Morozov; Marina Morozova; Dmitry Shabliy; Anastasia Eduardovna Denga;

The aim of this study was to determine the effect of orthodontic tooth relocation on the periodontal condition in rats with experimental diabetes mellitus and to determine the possibility of preventing pathological changes using antidysbiotic agents. In experiments on white Wistar rats, the gums and periodontal bone tissue were isolated, and blood serum was also obtained. The level of biochemical markers of inflammation was determined in the gingival homogenate, and the activity of alkaline and acid phosphatases, the activity of elastase, as well as the content of calcium and protein, were determined in the homogenate of the periodontal bone tissue. The research results indicate the development of systemic inflammation, activation of lipid peroxidation, inflammation and an increase in contamination of opportunistic microbiota on the gums, the development of dysbiosis against the background of a decrease in antimicrobial protection in the oral cavity. The results give grounds to recommend the use of the investigated antidysbiotics before orthodontic tooth relocation in patients with diabetes mellitus.


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Keywords: rats, experiment, diabetes, orthodontics

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy