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https://doi.org/10.14300/mnnc.2020.15076

Hemocoagulation and lipoperoxidation processes and mechanisms of renal osmoregulatory function’s impairment in chronic intoxication with chromium compounds

[Experimental medicine]
Elmira Gagloeva; Vadim Brin; Varvara Ahpolova;

The prolonged intake of chromium into the body of experimental animals leads to the development of toxic nephropathy, accompanied by significant violations of hemocoagulation and lipid peroxidation processes. Correlation relationships between the changes in the indicators of renal osmoregulatory function and the changes in the indicators of anticoagulant and fibrinolytic links of the hemostatic system and the level of thrombinemia were revealed. These effects correlated with an increase in the level of lipid peroxidation products and a decrease in the activity of antioxidant blood enzymes. The results of the study make it possible to pathogenetically reasonably recommend the use of anticoagulants and antioxidants for the development of methods for the prevention and correction of the manifestations of toxic nephropathy when the body is exposed to chromium compounds.

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Keywords: chromium, hemostasis, lipid peroxidation, kidney function