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https://doi.org/10.14300/mnnc.2020.15073

Dependence of the severity of haloperidol catalepsy on the activity of dopaminergic and glutamatergic systems of the brain of rats with prolonged use of antipsychotics

[Experimental medicine]
Mariya Baturina; Eduard Beyer; Vladimir Baturin; Alexey Popov;

Long-term (30 days) use of haloperidol in doses of 0.1 and 0.5 mg/kg reduced the cataleptogenic effect of this antipsychotic. This was accompanied by an increase in dopamine receptors of the first type and NMDA-receptors (subunit of NMDA2A) in the forebrain tissue. Risperidone, which has a slightly different mechanism of neurotropic action, also limited the severity of catalepsy, although this effect was less pronounced and was accompanied by an increase in the number of NMDA2B subunits of NMDA receptors. The use of both drugs increased the levels of autoantibodies in the blood of animals to both dopamine and NMDA receptors. Correlation analysis revealed a positive relationship between the number of NMDA2A receptors and the intensity of the cataleptogenic effect. In contrast, high levels of autoantibodies to NMDA2A receptors coincided with a less pronounced cataleptogenic effect of haloperidol.

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Keywords: antipsychotics, haloperidol, risperidone, catalepsy, dopamine receptors, NMDA-receptors, autoantibodies