• Main page
• About the journal
• Editorial board
• Subscription
• Information for contributors
• Editorial and Peer Review
• Issues archive
• Authors
• Articles
  • By alphabet
  • By category
• Blogs and comments

The journal is included into The list of leading scientific periodicals.

The journal is included into VINITI database and is registered in Electronic scientific library.

The journal is indexed by SCOPUS, Ulrich's International Periodicals Directory.

EBSCO

https://doi.org/10.14300/mnnc.2020.15059

Phenotypic characteristics of lymphocyte populations and the level of the proinflammatory mediators in women with leiomyoma in reproductive

[Obstetrios and gynecology]
Olga Yurievna Sevostyanova; Guzel Nukhovna Chistyakova; Irina Ivanovna Remizova; Natalia Evgenievna Sevostyanova; Natalia Evgenievna Sevostyanova; Tatiana Evgenievna Byzova;

The research objective was to study the characteristics of the structure of lymphocyte population and subpopulation and the content of proinflammatory mediators in patients with uterine leiomyoma at reproductive age. There were examined 220 patients of reproductive age, 190 of them with uterine leiomyoma and 30 healthy women. High content of T-lymphocytes with Fas-receptors and a significantly high level of proinflammatory mediators (tumornecrotic factor alpha, β-interferon and C-reactive serum protein), the primary fibroblast growth factor on the background of an γ-interferon deficiencywere obtained in patients of reproductive age with uterine leiomyoma. The conclusion was made about the activation of factors of adaptive immunity and proinflammatory mediators in women of reproductive age with uterine leiomyoma.

Download

References:

1. Clinical recommendation. Uterine myoma: diagnosis, treatment and rehabilitation. Letter from the Ministry of health of the Russian Federation dated 02.10.2015. № 15-4/10/5805. Аkusherstvo i ginekologiya. – Obstetrics and gynecology. 2016;4(Suppl.):342. (In Russ.).
2. Forth D., Rӧhl F. W., Friedrich C., Tylkoski H., Rӧmer T. [et al.]. Symptoms of uterine myomas: data of epidemiological study in Germany. Arch. Gynecol. Obstet. 2017;295(2):415- 426. https://doi.org/10.1007/s00404-016-4239-y
3. Drayer S. M., Catherine W. H. Prevalence, morbidity, and current medical management of uterine leiomyomas. Int. J. Gynaecol. Jester. 2015;131(2):117-122. https://doi.org/10.1016/j.ijgo.2015.04.051
4. Shapovalova F. I. Uterine Fibroid and reproduction. Zhurnal akusherstva i zhenskikh boleznej. – Journal of Obstetrics and Women/ s Diseases. 2019;68(1)93-101. (In Russ.). https://doi.org/10/17816/JOWD681930101
5. Dvorovska D., Brany D., Dankova Z., Halasova E., Visnovsky J. Molecular and clinical attributes of uterine leiomyoma/ s. Tumor Biology. 2017;39(6):116. https://doi.org/10.1177/1010428317710226
6. Ciarmela P., Islam M. S., Reis F. M., Gray P. C., Bloise E. [et al.]. Growth factors and myometrium: Biological effects in uterine fibroid and possible clinical implications. Hum. Reprod. Update. 2011;17:772-790. https://doi.org/10.1093/humupd/dmr031
7. Islam M. S., Protic O., Stortoni P., Grechi G., Lamanna P. [et al.]. Complex networks of multiple factors in the pathogenesis of uterine leiomyoma. Fertil. Steril. 2013;100:178- 193. https://doi.org/10.1016/j.fertnstert.2013.03.007
8. Maruo T., Ohara N., Wan J., Matsuo H. Sex steroidal regulation of uterine leiomyoma growth and apoptosis. Hum. Reprod. Update. 2004;10:207-220. https://doi.org/10.1093
9. Borahay M. A., Asoglu M. R., Mas A., Adam S., Kilic G. S., Al-Hendy A. Estrogen receptors and signaling in fibroids: Role in pathobiology and therapeutic implications. Reprod. Sci. 2017;24:1235-1244. https://doi.org/10.1177/1933719116678686
10. Ciebiera M., Wlodarczyk M., Wrzosek M., Slabuszewska-Jozwiak A., Nowicka G., Jakiel G. Ulipristal acetate decreases transforming growth β3 serum and tumor tissue concentrations in patients with uterine fibroids. Fertil. Steril. 2018;109(3):501-507. https://doi.org/10.1016/j.fertnstert.2017.11.023
11. Order of the Ministry of health of the Russian Federation of 01.11.2012 № 572-n «On approval of the procedure for medical help in the profile of «obstetrics and gynecology» (except for assisted reproductive technologies)». (In Russ.). https://www.rosminzdrav.ru/
12. Shramko S. V., Zorina V. N., Zorin N. A., Botvinyeva L. A., Archipova S. V., Likhacheva V. V. Interpretation of steroid receptor gene expression in uterine tissue and serum concentrations of immunoregulatory proteins, cytokines, sex steroids in proliferative diseases. Meditsinskaya immunologiya. – Medical Immunology. 2018;20(5):731-738. (In Russ.). https://doi.org/10.15789/1563-0625-2018-5-731-738
13. Islam M. S., Ciavattini A., Petraglia F., Castelucci M., Ciamela H. Etracellular matrix in uterine leiomyoma pathogenesis: a potential target for future therapeutics. Hum. Reprod. Update. 2018;24(1):59-85. https://doi.org/10.1093/humupd/dmx032
14. Ciebiera M., Wlodarczyk M., Zgliczynska M., Lukaszuk K., Meczekalski B. [et al.]. The role of Tumor Necrosis Factor α in the Biology of Uterine Fibroids and Related Symptoms. Int. J. Mol. Sci. 2018;19(12):38-69. https://doi.org/10/3390/ijms19123869
15. Konenkov V. I., Koroleva E. G., Orlov N. B., Prokofiev V. F., Shevchenko A. V., Novikov A. M. Serum levels of hemopoietic and angiogenesis growth factors. Meditsinskaya immunologiya. – Medical Immunology. 2018;20(5):691-698. (In Russ.). https://doi.org/10.15789/1563-0625-2018-5-691-698
16. Islam M. S., Greco S., Janjusevic V., Ciavattini A., Giannubilo S. R. [et al.]. Growth factors and pathogenesis. Best. Pract. Res. Clin. Obstet. Gynecol. 2016;34:25-36. https://doi.org/10.1016/j.bpobgyn.2015.08.018

Keywords: uterine leiomyoma, reproductive age, lymphocyte populations, T-lymphocyte subpopulations, proinflammatory mediators