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ISSN 2073-8137
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Microflora of the respiratory tract in children with cystic fibrosis of the Stavropol territory

[Cystic fibrosis]
Ella Vodovozova; Larisa Ledeneva; Inna Samvelovna Grigoryants; Elena Alexandrovna Enina;

Chronic respiratory infection in cystic fibrosis is a leading factor in determining the prognosis of the disease. Thе work investigated the spectrum of the microflora of the respiratory tract in children of the Stavropol Territory suffering from cystic fibrosis. The microflora was determined in sputum, deep smears from the posterior pharyngeal wall, bronchial secretions obtained during bronchoscopy in 54 patients with cystic fibrosis aged from 1 to 18 years. In the period from 2015 to 2018, the leading role of St. aureus, Ps. aeruginosa and Str. pyogenes was revealed. Moreover, a decrease in the share of St. aureus (from 60.8 to 36.5 %), Str. pyogenes (from 15.6 to 11.5 %) and the growth of Ps. aeruginosa (from 15.7 to 26.9 %) is noted. Thus, in the Stavropol Territory, infection with gram negative flora is growing in children with cystic fibrosis, while Ps. aeruginosa is of particular concern.

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References:
1. Ivanova O. N. Cystic fibrosis in children. Uspehi sovremennoj nauki. – Successes of modern science. 2017;7:180-183. (In Russ.).
2. Polikarpova S. V., Kondratyeva E. I., Shabalova L. A., Pivkina N. V., Zhilina S. V. [et al.]. Microflora of the respiratory tract in patients with cystic fibrosis and sensitivity to antibiotics based on a 15-year follow-up. Medicinskij Sovet. – Medical council. 2016;15:84-89. (In Russ). https://doi.org/10.21518/2079-701x-2016-15-84-89
3. Kapranova N. I., Kashirskaya N. Yu. Mukovistsidoz. Moscow, 2014. (In Russ). 4. Ah-Fong Hoo, Lena P. Thia, The Thanh Diem Nguoen, Andrew Bush [et al.]. Lung finction is abnormal in 3-month-old infants with cystic fibrosis diagnosed by newborn screening. Thorax. 2012;67(10):874-888. https://doi.org/10.1136/thoraxjnl-2012-201747
5. Asherova I. K. Prevalence and reservoirs of A. xylosoxidans and S. maltophilia in cystic fibrosis center. 21th ERS Annual Congress. Amsterdam, Netherlands. 2011;38(55):61. https://doi.org/10.18093/0869-0189-2012-0-2-65-70
6. Ben Haj Khalifa A., Moissenet D., Vu Thien H., Khedher M. Virulence factors in Pseudomonas aeruginosa: mechanisms and modes of regulation. Ann. Biol. Clin. Paris. 2011;69(4):393-403. https://doi.org/10.1684/abc.2011.0589
7. Register of cystic fibrosis patients in the Russian Federation. Mukoviscidoz. Ed. by Amelina E. L., Kashirskaya N. Yu., Kondratieva E. I., Krasovsky S. A., Starinova M. A. 2020. (In Russ.).
8. Pavlinova E. B., Mingairova A. G., Safonova T. L., Kirshina I. A. [et al.]. The clinical significance of pulmonary microbiota and the experience of using inhaled antibacterial therapy in children of the Omsk cystic fibrosis center. Pediatricheskaja farmakologija. – Pediatric pharmacology. 2018;2:121-128. (In Russ.). https://doi.org/10.15690/pf.v15i2.1868
9. Shaginjan I. A., Chernuha M. Ju., Kapranov N. I. [et al.]. Consensus «Cystic fibrosis: definition, diagnostic criteria, therapy. Moscow, 2016. (In Russ.).
10. Asherova I. K., Kapranov N. I. Cystic fibrosis. Medical and social problem. Yaroslavl , 2013. (In Russ.).
11. Baturin V. A., Shсhetinin E. V., Demidenko I. F. Assessment of antibiotic resistance Klebsiella spp. and Acinetobacter spp. in hospitals of the city of Stavropol. Medicinskii vestnik Severnogo Kavkaza. – Medical News of North Caucasus. 2014;9(2):184-185. (In Russ.). https://doi.org/10.14300/mnnc.2014.09052

Keywords: cystic fibrosis, airway microflora


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