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Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
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Study of safety and specific activity of a new combination of syrup with thyme extract and ambroxol compared to «Pertussin» syrup

[Abstracts]
Alina Umarovna Gagueva; Alexander Yuryevich Terekhov; Elena Olegovna Sergeeva;

At the work was to study the subchronical toxicity and specific pharmacological activity of the combined drug (syrup with thyme extract and Ambroxol) compared to the official drug «Pertussin». The study was performed on outbred Wistar rats with oral administration of substances at a dose of 3.8 ml/kg per day for 14 days. The equitoxicity of the test drug and the comparison drug was proved. It has been found that the administration of the test drug under experimental conditions was accompanied by a more intensive stimulation of bronchial secretion.

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3. Knyazheskaya N. P., Chuchalin A. G. Justification of the choice of a drug for the treatment of cough syndrome
and diseases accompanied by sputum secretion. Russkij medicinskij zhurnal. – Russian medical journal.
2007;15(18):1312-1316. (In Russ.).
4. Morice A. H., Kantar A., Dicpinigaitis P. V. [et al.] Treating acute cough: wet versus dry – have we got the paradigm wrong? ERJ Open. Res. 2015;1:00055-2015.
5.Krasovsky G. N., Rakhmanin Yu. A., Egorov N. A. The Extrapolation of Toxicological data from animals to humans. Moscow: Meditsina, 2009. (In Russ.).

Keywords: safety, efficiency, expectorant effect, mucolytics, thyme extract, ambroxol, «Pertussin»


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