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Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
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The prevalence of single-nucleotide polymorphisms CYP2С19*2 and CYP2С19*3 in russians population of Stavropol territory

[Abstracts]
Anna Tsarukyan; Vladimir Baturin;

A study of the prevalence of CYP2C19*2 and CYP2C19*3 in the russian ethnic group of Stavropol Territory has been carried out. The total carrier frequency of the «slow» CYP2С19 alleles studied was 42 %. The results obtained may assist in making decisions on the use of pharmacogenetic examination for selection of the dosage regimens for CYP2С19 drug substances.

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References:
1. Scott S. A., Sangkuhl K., Shuldiner A. R. [et al.]. PharmGKB summary: Very important pharmacogene information for cytochrome P450, family 2, subfamily C, polypeptide 19. Pharmacogenetics and Genomics. 2012;20:520-23.
https://doi.org/10.1097/FPC.0b013e32834d4962
2. PharmVar. The table represents the PharmVar core alleles. Available at: www.pharmvar.org/gene/CYP2C19
Version 4.1.4 Accessed February 14, 2020.
3. Shuldiner A. R., O’Connell J. R., Bliden K. P., Gandhi A., Ryan K. [et al.]. Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy. JAMA. 2009;302:849-857.
https://doi.org/10.1001/jama.2009.1232
4. Gardiner S. J., Begg E. J. Pharmacogenetics, DrugMetabolizing Enzymes, and Clinical Practice. Pharmacol. Rev. 2006;58:521-590. https://doi.org/10.1124/pr.58.3.6
5. Mirzaev K. B., Fedorinov D. S., Ivashchenko D. V., Sychev D. A. Multi-Ethnic Analysis of Cardiac Pharmacogenetic Markers of Cytochrome p450 and Membrane Transporters Genes in the Russian Population. Racionalnaja Farmakoterapija v Kardiologii. – Rational Pharmacotherapy in Cardiology. 2019;15(3):393-406. (In Russ.)https://doi.org/10.20996/1819-6446-2019-15-3-393-406

Keywords: pharmacogenetics, cytochrome P450, CYP2C19, genetic polymorphism


Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy