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Histological and immunohistochemical features of reparative osteogenesis in standard bone defects of the mandible, replaced by synthetic biomaterial using a membrane-free technology

[Experimental medicine]
Sergey Sirak; Anton Andreev; Sergey Rubnikovich; Alexandr Sletov; Zuhra Magomedovna Kochkarova; Nikolay Dmitrievich Wafiadi; Vadim Nikolaevich Lenev; Evgeny Shchetinin;

The article presents the results of an experimental evaluation of the effectiveness of an osteoplastic composition consisting of a mixture of calcium hydroxyapatite, β-tricalcium phosphate, a granule bonding activator and hyaluronic acid for the plasticization of standard jaw bone defects. In 30 year-old rabbits, it was found that synthetic biomaterials do not cause pathological reactions in the surrounding bone tissue, are absorbed synchronously with the construction of bone repair, are quickly replaced by the emerging bone structures, which causes the complete replacement of the bone defect with a corn, which is rebuilt into Mature bone. The addition of 60 % calcium hydroxyapatite and 40 % β-tricalcium phosphate to the resorbed two-phase mixture with the bio Linker granule bonding activator of hyaluronic acid potentiates the osteostimulating effect of the entire composition and accelerates the reparative osteogenesis, and the significant porosity creates optimal conditions for the germination of cellular bone tissue in the gaps between the granules


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Keywords: bone defect, synthetic biomaterials, osteogenesis, repair, hyaluronic acid

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy