• Main page
• About the journal
• Editorial board
• Subscription
• Information for contributors
• Editorial and Peer Review
• Issues archive
• Authors
• Articles
  • By alphabet
  • By category
• Blogs and comments

The journal is included into The list of leading scientific periodicals.

The journal is included into VINITI database and is registered in Electronic scientific library.

The journal is indexed by SCOPUS, Ulrich's International Periodicals Directory.

EBSCO

https://doi.org/10.14300/mnnc.2020.15019

The role of the genetic polymorphism of thrombocyte integrins (ITGΑ2, ITGΒ3) in the pathogenesis of non-traumatic aseptic necrosis of the femoral head

[Orthopedics and traumatology]
Mikhail Panin; Nikolay Zagorodny; Larisa Mikhailovna Samokhodskaya; Andrey Lipov;

In order to estimate the role of platelet ITGα2 и ITGβ3 genes’ polymorphisms in avascular necrosis of femoral head a comparative analysis of the frequency of allelic variants of ITGα2 and ITGβ3 integrin genes was carried out in 41 patients and in 320 healthy subjects. It was found that the frequency of the homozygous TT genotype of the ITGα2 gene in patients with aseptic necrosis of the femoral head was 6.5 times higher than in the control group. The detection rate of the C allele in the ITGβ3 gene was also significantly higher in patients with osteonecrosis: 41.5 % vs 27.5 % in the control group. Statistically significant differences were also found in the frequency of the homozygous SS genotype of the ITGβ3 gene: 4.9 % in the main group vs 1.6 % in the control group. The identified genetic characteristics may indicate the importance of the genes ITGα2 and ITGβ3 polymorphism in the pathogenesis of aseptic necrosis of the femoral head. As the «predisposition genes» for aseptic necrosis of the femoral head, TT genotypes of the ITGα2 gene and CC of the ITGβ3 gene and, especially, their combination should be considered.

Download

References:
1. Shannon B. D., Trousdale R. T. Femoral osteotomies for avascular necrosis of the femoral head. Clin. Orthop. Relat. Res. 2004;418:34-40.
2. DeSmet A. A., Dalinka M. K., Alazraki N. P. [et al.]. Expert Panel on Musculoskeletal Imaging. Avascular necrosis of the hip. VA: American College of Radiology (ACR), 2005.
3. Mont M. A., Marulanda G. A., Jones L. C. [et al.]. Systematic analysis of classifi cation systems for osteonecrosis of the femoral head. J. Bone Joint Surg. 2006;88(3):16-26. https://doi.org/10.2106/JBJS
4. Panin M. A., Zagorodny N. V., Karchebny N. N., Sadkov I. A., Petrosyan A. S., Zakirova A. R. Modern view to the pathogenesis of non-traumatic osteonecrosis. Vestnik travmatologii I ortopedii imeni N. N. Priorova. – Journal or traumatology and orthopedics named after N. N. Priorov. 2017;(2):69-75. (In Russ.).
5. Jones, L. C., Mont M. A., Le T. B. Procoagulants and osteonecrosis. J. Rheumatol. 2003;30:783-791.
6. Glueck C. J., Freiberg R. A., Oghene J. [et al.]. Association between the T-786C eNOS polymorphism and idiopathic osteonecrosis of the head of the femur J. Bone Joint Surg. 2007;89:2460-2468. https://doi.org/10.2106/JBJS.F.01421
7. Chandler F. A. Coronary disease of the hip. 1949. Clin. Orthopaed. Relat. Res. 2001;386:7-10. https://doi.org/10.1097/00003086-200105000-00002
8. Tuckwell D. S., Smith L., Korda M. [et al.]. Monoclonal antibodies identify residues 199-216 of the integrin alpha2 vWFA domain as a functionally important region within alpha2 beta1. Biochem. J. 2000;350:485-493.
9. Leone A. M., De Stefano V., Burzotta F. [et al.]. Scientific letters. Glycoprotein Ia C807T gene polymorphism and increased risk of recurrent acute coronary syndromes: a five year follow up. Heart. 2004;90:567-569.
10. Fullard J. F. The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis. Curr. Pharm. Des. 2004;14:1567-1576. https://doi.org/10.2174/1381612043384682
11. Smith F. B., Connor J. M., Lee A. J. [et al.]. Relationship of the platelet glycoprotein PlA and fibrinogen T/G+1689 polymorphisms with peripheral arterial disease and ischaemic heart disease. Thromb. Res. 2004;112:209-216. https://doi.org/10.1371/journal.pone.0101518
12. Kucharska-Newton A. M., Monda K. L., Campbell S. [et al.]. Association of the platelet GPIIb/IIIa polymorphism with atherosclerotic plaque morphology: the Atherosclerosis Risk in Communities (ARIC) Study. Atherosclerosis. 2011;216:151-156. https://doi.org/10.1016/j.atherosclerosis.2011.01.038
13. Verschuren J. J. W., Boden H., Wessels J. A. M. Value of platelet pharmacogenetics in common clinical practice of patients with ST-segment elevation myocardial infarction. J. Eur. Heart. 2012;33:516.
14. Pamukcu B., Oflaz H., Nisanci Y. The role of platelet glycoprotein IIIa polymorphism in the high prevalence of in vitro aspirin resistance in patients with intracoronary stent restenosis. Am. Heart J. 2005;149:675-680.
15. Narayanan A., Khanchandani P., Borkar R. M. [et al.]. Avascular Necrosis of Femoral Head: A Metabolomic, Biophysical, Biochemical, Electron Microscopic and Histopathological Characterization. Scientific Reports. 2017;7.
16. Andreenko E. Y., Samokhotskaya L. M., Balatsky A. V., Makarevich P. I., Boytsov S. A. The prognostic value of allele polymorphisms genes determining hemostasis and their combinations with known risk factors in ischemic cardiac disease development. Kardiovaskularnaya terapia I profilaktika. – Cardiovascular therapy and prophylaxis. 2011:8:32-39 (In Russ.).
17. Kunicki T. J., Kritzik M., Annis D. S., Nugent D. J. Hereditary variation in platelet integrin alpha-2-beta-1 density is associated with two silent polymorphisms in the alpha-2 gene coding sequence. Blood. 1997;89:1939-1943.

Keywords: aseptic necrosis of the femoral head, avascular necrosis, pathogenesis retraumatize-tion necrosis, integrins polymorphisms of platelet, genes predisposition