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Assessment of proliferative activity and apoptosis in patients with autoimmune thyroiditis

[Original research] [Morphology]
Valentina Botasheva; Grigory Dzhikarv; Olesya Sevryukova;

The proliferative activity of various tissues of the thyroid gland in autoimmune thyroiditis was assessed by means of immunohistochemical method. The high proliferative activity of lymphoid tissue, a moderate proliferative activity of thyrocytes in lymphocyte infiltration and low outside were detected. Also noted the intense expression of Fas on thyrocytes close to lymphoid infiltration that is an evidence of immunologically caused death of the thyroid epithelium.

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References:
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2. Gurevich, L.E., Kazantseva I.A., Fedosenko A.K. Arkh. patologii. 2001;4:18–21.
3. Basolo F. Lab.Invest. 2000;80(9)1413–1419.
4. Di Pasquale M., Palazzo J.P., Rothstein J.L. Hum. Pathol. 2001;32(1):24–30.
5. Fehr-Merhof A., Flury R., Ruttimann S. Schweiz. Med.Wschr. 1999;129:883–889.

Keywords: autoimmune thyroiditis, apoptosis, proliferation, thyroid gland