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https://doi.org/10.14300/mnnc.2017.12090

Studying the geroprotective effects of inhibitors suppressing aging -associated signaling cascades in model organisms

[Reviews]
Alexey Moskalev; Mikhail Shaposhnikov; Ilya Solovev;

According to DrugAge (http://genomics.senescence.info/drugs/) and Geroprotectors.org (http://geroprotectors. org/) databases nowadays more than 200 compounds which elongate lifespan of model organisms exist. One of the most promising approaches constitutes aging-associated pathways (insulin/IGF-1, mTOR, NF-κB, PI3k, etc.) as main targets for new perspective geroprotectors’ screening. In the current review we summarized the data touching upon geroprotectors that target signaling pathways which are involved in stress-response, metabolism, growth and proliferation, inflammation, apoptosis, etc. Some our results on Drosophila melanogaster and Caenorhabditis elegans models confirm the effectiveness of pathways of aging inhibition approach to the search for new geroprotectors.

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Keywords: longevity, aging, geroprotector, signaling cascades pathways, model organisms