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https://doi.org/10.14300/mnnc.2017.12084

Changes in calcifediol concentrations in infants depending on the cholecalciferol dose and duration of therapy

[Pediatrics]
Leonid Klimov; Irina Zakharova; Stanislav Maltcev; Svetlana Malyavskaya; Anastasiya Yagupova; Svetlana Dolbnya; Аnna Kasyanova; Victoria Kuryaninova; Dmitry Bobryshev;

The paper presents an analysis of the relationship between the duration of cholecalciferol supplementation at different doses and the 25(ОН)D concentration in infants during their first year of life. We evaluated 496 infants aged 1 month to 12 months who were divided into four groups depending on the duration of vitamin D supplementation: up to 8 weeks, 8–15 weeks, 16–24 weeks, and over 24 weeks.

The results obtained in this study demonstrate rather low vitamin D levels in infants, both breastfed and formula-fed. It was demonstrated that use of higher (1000–1500 IU/day) prophylactic doses of vitamin D than the conventionally used 500 IU/day dose is justified if the aim is to maintain an optimal serum calcifediol concentration (30 ng/mL or
higher) in infants in their first year of life, and that the optimal duration of a supplementation course is not less than 16 weeks.

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Keywords: cholecalciferol, vitamin D insufficiency, infants, first year of life, prevention, duration of supplementation, feeding